ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $79.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Acta Biochim Pol.2015, 62(2):253-8J Ethnopharmacol.2017, 198:205-213Anal Chim Acta.2018, 1039:162-171PLoS One.2018, 13(11):e0208055Nat Commun.2019, 10(1):5169ACS Chem Biol.2019, 14(5):873-881BMC Complement Altern Med....2019...Asian Pac J Cancer Prev....2019...
Int J Mol Sci.2019, 20(14):E3538Int J Mol Sci.2019, 20(8):E1855Int J Mol Sci.2019, 20(9):E2244Molecules.2019, 24(16):E3003Molecules.2019, 24(24),4583Int J Oncol.2019, 55(1):320-330Phytomedicine.2019, 59:152785Planta Med.2019, 85(3):217-224
Process Biochemistry2019, 87:213-220Metabolites.2019, 9(11):E271LWT-Food Sci Technol2020, 109163Molecules2020, 25(4):892Food Chem.2020, 313:126079Appl. Sci.2020, 10(5),1713.J of Applied Biological Chem....2020...
Our products had been exported to the following research institutions and universities, And still growing.
Calcutta University (India)Universidade Federal de Pernamb... (Brazil)Vin?a Institute of Nuclear Scie... (Serbia)University of Queensland (Australia)
University of Wollongong (Australia)Florida A&M University (USA)Michigan State University (USA)University of Auckland (New Zealand)
University of Zurich (Switzerland)Universiti Sains Malaysia (Malaysia)Utah State University (USA)
Related Screening Libraries
||Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor. |
||PARP | Caspase | Akt | ERK | PPAR|
|Life Sci. 2006 Jan 2;78(6):607-13. |
|Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.[Pubmed: 16112686]|
|The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor. |
METHODS AND RESULTS:
A lanostane-type triterpene acid, Dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of Poria cocos (Polyporaceae). Dehydrotrametenolic acid selectively inhibited the growth of H-ras transformed cells with a GI(50) value of 40 microM. FACS analysis indicated that the compound exerted its anti-proliferation effects through cell cycle arrest at G2/M phase and accumulation of sub-G1 population. Dehydrotrametenolic acid-induced apoptosis was further confirmed with chromosomal DNA fragmentation, caspase-3 activation, and degradation of PARP and Lamin A/C degradation. The compound also regulated the expression of H-ras, Akt and Erk, which are the downstream proteins of H-ras signaling pathways.
The results suggest that Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor.
|Biol Pharm Bull. 2002 Jan;25(1):81-6. |
|Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of noninsulin-dependent diabetes mellitus to insulin.[Pubmed: 11824563]|
|We recently discovered that the triterpene acid compound Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal plant. |
METHODS AND RESULTS:
We examined the effects of Dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.
This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.
Dehydrotrametenolic acid Description
||The roots of Wolfiporia cocos (Schw.) Ryv.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.