4-Hydroxybenzylamine | CAS:696-60-6 | Manufacturer ChemFaces

4-Hydroxybenzylamine

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Description:

4-Hydroxybenzaldehyde derivatives are inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), 4-Hydroxybenzylamine also shows the competitive inhibition on GABA-T with respect to GABA.

Targets:

GABA Receptor

In vitro:

Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.

Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.[Pubmed: 16290145 ]

4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).
METHODS AND RESULTS:
Investigation of structure-activity relation revealed that a carbonyl group or an amino group as well as a hydroxy group at the para position of the benzene ring are important for both enzymes' inhibition. HBA was shown to give competitive inhibition of GABA-T with respect to alpha-ketoglutarate and competitive inhibition of SSADH. 4-Hydroxybenzylamine (HBM) also showed the competitive inhibition on GABA-T with respect to GABA.
CONCLUSIONS:
In conclusion, the inhibitory effects of HBA and HBM on both enzymes could result from the similarity between both molecules and the two enzymes' substrates in structure, as well as the conjugative effect of the benzene ring. This suggested that the presence of the benzene ring may be accepted by the active site of both enzymes, HBA and HBM may be considered as lead compounds to design novel GABA-T inhibitors.

4-Hydroxybenzylamine Description

Source:	The herbs of Reseda media
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	4-Hydroxybenzylamine
Price:
CAS No.:	696-60-6
Catalog No.:	CFN00081
Molecular Formula:	C₇H₉NO
Molecular Weight:	123.15 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Reseda media
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library GABA Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	8.1202 mL	40.6009 mL	81.2018 mL	162.4036 mL	203.0045 mL
5 mM	1.624 mL	8.1202 mL	16.2404 mL	32.4807 mL	40.6009 mL
10 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
50 mM	0.1624 mL	0.812 mL	1.624 mL	3.2481 mL	4.0601 mL
100 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL

CFN00052	2-Amino-1-phenylethanol	111025-00-4	241.29	C₁₅H₁₅NO₂
CFN00053	N-Benzoyl-2-hydroxy-2-phenylethylamine	111059-46-2	241.29	C₁₅H₁₅NO₂
CFN00054	Muricatide	111025-01-5	283.33	C₁₇H₁₇NO₃
CFN00064	Benzylamine	100-46-9	107.15	C₇H₉N
CFN00065	N-Methylbenzylamine	103-67-3	121.18	C₈H₁₁N
CFN00079	2-Hydroxybenzylamine	932-30-9	123.15	C₇H₉NO
CFN00080	3-Hydroxybenzylamine	73604-31-6	123.15	C₇H₉NO
CFN00081	4-Hydroxybenzylamine	696-60-6	123.15	C₇H₉NO
CFN89344	Niazinin	147821-57-6	343.39	C₁₅H₂₁NO₆S
CFN89363	Niazimicin	147821-49-6	357.42	C₁₆H₂₃NO₆S