6-Acetonyldihydrochelerythrine | CAS:22864-92-2

6-Acetonyldihydrochelerythrine

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Product Name	6-Acetonyldihydrochelerythrine
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CAS No.:	22864-92-2
Catalog No.:	CFN98233
Molecular Formula:	C₂₄H₂₃NO₅
Molecular Weight:	405.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The root barks of Toddalia aculeata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 cell lines, it displays potent cytotoxic activity in human HCT116 and SW620 colon carcinoma cells, to a higher extent than 5-fluorouracil (5-FU), the cornerstone chemotherapeutic agent in colon cancer.

Targets:

ERK | Akt | p53 | Bcl-2/Bax | PPAR | HIV

In vitro:

Planta Med. 2003 Feb;69(2):148-52.

Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.[Pubmed: 12624820]

METHODS AND RESULTS:
Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridine alkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods. The isolated alkaloids 6-Acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidative activity on thiocyanate assays, free radical scavenging activity, β β β β β-carotene bleaching method, and deoxyribose assay.
CONCLUSIONS:
All alkaloids exhibited significant antioxidant activities in linoleic acid and β β β β β-carotene. Although afforded protection against the damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavenging effects on the 1,1-diphenyl-2-picrylhydrazyl radicals.

Ars Pharmaceutica,2003,44(1):5-21.

Actividad antioxidante de los alcaloides de Bocconia arborea. Estudio sobre seis métodos de análisis Antioxidant activity of alkaloids from Bocconia arborea. A study on six testing methods[Reference: WebLink]

6-Acetonyldihydrochelerythrine Description

Source:	The root barks of Toddalia aculeata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antiviral Compound Library Cytotoxic Compound Library Pro-apoptotic Compound Library Alkaloids Compound Library PPAR Inhibitor Library p53 Inhibitor Library HIV Inhibitor Library ERK Inhibitor Library Bcl-2/Bax Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4661 mL	12.3305 mL	24.6609 mL	49.3218 mL	61.6523 mL
5 mM	0.4932 mL	2.4661 mL	4.9322 mL	9.8644 mL	12.3305 mL
10 mM	0.2466 mL	1.233 mL	2.4661 mL	4.9322 mL	6.1652 mL
50 mM	0.0493 mL	0.2466 mL	0.4932 mL	0.9864 mL	1.233 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.4932 mL	0.6165 mL

CFN98259	Sanguinarine	2447-54-3	332.3	C₂₀H₁₄NO₄
CFN92810	Dihydrosanguinarine	3606-45-9	333.1	C₂₀H₁₅NO₄
CFN89299	6-Methoxydihydrosanguinarine	72401-54-8	363.36	C₂₁H₁₇NO₅
CFN89308	6-Ethoxydihydrosanguinarine	28342-31-6	377.39	C₂₂H₁₉NO₅
CFN91469	Angoline	21080-31-9	379.4	C₂₂H₂₁NO₅
CFN91468	6-Ethoxydihydrochelerythrine	7441-89-0	393.4	C₂₃H₂₃NO₅
CFN92811	Norsanguinarine	522-30-5	317.1	C₁₉H₁₁NO₄
CFN91002	Oxysanguinarine	548-30-1	347.3	C₂₀H₁₃NO₅
CFN98449	Chelerythrine	34316-15-9	348.4	C₂₁H₁₈NO₄
CFN95373	Bocconoline	32906-88-0	379.4	C₂₂H₂₁NO₅