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7',8'-Dihydroobolactone
7',8'-Dihydroobolactone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 7',8'-Dihydroobolactone
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CAS No.: 1240403-82-0
Catalog No.: CFN96889
Molecular Formula: C19H20O4
Molecular Weight: 312.36 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Oil
Source: The leaves of Cryptocarya obovata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
Targets: Antifection
In vitro:
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4057-9.
7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.[Pubmed: 20558060 ]

METHODS AND RESULTS:
Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-Dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis.
CONCLUSIONS:
7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
7',8'-Dihydroobolactone Description
Source: The leaves of Cryptocarya obovata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2014 mL 16.0072 mL 32.0143 mL 64.0287 mL 80.0359 mL
5 mM 0.6403 mL 3.2014 mL 6.4029 mL 12.8057 mL 16.0072 mL
10 mM 0.3201 mL 1.6007 mL 3.2014 mL 6.4029 mL 8.0036 mL
50 mM 0.064 mL 0.3201 mL 0.6403 mL 1.2806 mL 1.6007 mL
100 mM 0.032 mL 0.1601 mL 0.3201 mL 0.6403 mL 0.8004 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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