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    7-O-Prenylscopoletin
    Information
    CAS No. 13544-37-1 Price
    Catalog No.CFN92639Purity>=98%
    Molecular Weight260.3Type of CompoundCoumarins
    FormulaC15H16O4Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: 7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
    Targets: CDK | PLK
    In vitro:
    Planta Medica, 2012 , 78 (11) :1201-1201.
    Mechanistic study of O-methylcedrelopsin and dehydrogeijerin[Reference: WebLink]
    Plants that can survive in the harsh environment of South Texas have the potential to produce molecules with activity against diverse biological targets. The Mountain torchwood, Amyris madrensis, was evaluated because the crude lipophilic extract had potent activity against prostate cancer cells. Multiple cytotoxic compounds were isolated using bioassay guided fractionation including 14 previously identified coumarins. Two coumarins, O-methylcedrelopsin and dehydrogeijerin, were evaluated for antiproliferative activities against cancer cell lines. O-methylcedrelopsin has an IC50 of 7.8 and 27.8μM in HeLa and PC-3 cells respectively. Dehydrogeijerin also showed activity in the low micromolar range with an IC50 of 16.0μM in HeLa cells and 43.0μM in PC-3 cells. Both O-methylcedrelopsin and dehydrogeijerin caused a dose dependent accumulation of cells in G2/M as determined by flow cytometry. They have no effects on interphase microtubule structures or on the assembly of purified tubulin, suggesting a mechanism different from microtubule binding compounds. The compounds do however initiate the formation of abnormal mitotic spindles which closely resemble those formed following treatment of cells with mitotic kinase inhibitors. The hypothesis that O-methylcedrelopsin and dehydrogeijerin target mitotic kinases, specifically polo like kinase 1 (PLK1) or cyclin dependent kinase 1 (CDK1) is being tested. Two structurally similar coumarins, 7-O-Prenylscopoletin and cedrelopsin, were also identified but they have 10-fold lower antiproliferative potency. These structures will be informative in defining the moieties optimal for inhibiting mitotic progression.
    7-O-Prenylscopoletin Description
    Source: The herbs of Ptaeroxylon obliquum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.