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    Parishin C
    Information
    CAS No. 174972-80-6 Price
    Catalog No.CFN93114Purity>=98%
    Molecular Weight728.7Type of CompoundMiscellaneous
    FormulaC32H40O19Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Parishin C has antipsychotic effects, requires activation of 5-HT(1A) receptors, it can prevent vascular dementia.
    Targets: VEGFR | 5-HT Receptor
    In vivo:
    J Pharmacol Sci. 2010;113(4):404-8. Epub 2010 Jul 13.
    Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor.[Pubmed: 20644336]
    Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT(1A) receptor is an important therapeutic target of schizophrenia, we examined whether Parishin C affects phencyclidine-induced abnormal behaviors in mice.
    METHODS AND RESULTS:
    Phencyclidine-induced abnormal behaviors were significantly ameliorated by Parishin C. These effects were reversed by WAY 100635, a 5HT(1A)-receptor antagonist. Consistently, Parishin C showed high affinity at 5-HT(1A) receptor as well as a 5-HT(1A)-agonist activity in a 8-OH-DPAT-stimulated [(35)S]GTP-gammaS binding assay.
    CONCLUSIONS:
    Our results suggest that the antipsychotic effects of Parishin C require activation of 5-HT(1A) receptors.
    Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2668-73.
    Study on active ingredient and mechanism in preventing vascular dementia of Tianzhusan coming from Tujia medicine.[Pubmed: 26697697]
    To make clear of the absorbed components of Tianzhusan (TZS) and its possible mechanism in preventing vascular dementia (VD), the rats' models of VD were prepared by a permanent ligation of the bilateral common carotid arteries.
    METHODS AND RESULTS:
    After 60 days, rats were administrated with TZS for 0.1 g x kg(-1), and the volume is 0.02 mL x g(-1). After 3 days, the medicated serum was prepared and detected by UPLC, and then we predicted the possible chemical structure of the absorbed components of TZS. According to the absorbed components, the potential targets of TZS were found by ligand profiling of Discovery Studio 3.5. All of these target genes were submitted to DAVID onine for gene set enrichment analysis (GSEA). The 5 absorbed components of TZS have been predicted, and four of them have been identified as parishin B, Parishin C, parishin, pennogenin-3-O-alpha-L-rhamnopyranosy-(1-->2)-beta-D-glucoside. Through reverse finding targets, we got 861 pharmacophore models and 9 pathways from KEGG, BIOCARTA after document verification.
    CONCLUSIONS:
    These results showed that the efficacy mechanism of TZS on VD perhaps were be related with these absorbed components and pathways. If the traditional herbs could be proved effective by efficacy tests, the serum pharmacochemistry, computer-aided drug design, system biology and other technologies can be used in the next experiments, which will be beneficial to fast discovery of material basis and mechanisms of traditional medicine coming form ethnic minorities.
    Parishin C Description
    Source: The rhizomes of Gastrodia elata
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3723 mL 6.8615 mL 13.7231 mL 27.4461 mL 34.3077 mL
    5 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
    10 mM 0.1372 mL 0.6862 mL 1.3723 mL 2.7446 mL 3.4308 mL
    50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
    100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.2745 mL 0.3431 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chinese Journal of Experimental Traditional Medical Formulae, 2016, (18) :5-8.
    Comparison on Chemical Constituents and Pharmacological Effect of Gastrodiae Rhizoma Between Traditional Processing and Integration Processing[Reference: WebLink]
    To elucidate the rationality of integration processing technology based on comparison on chemical constituents and pharmacological effect of Gastrodiae Rhizoma between traditional processing and integration processing.
    METHODS AND RESULTS:
    Taking contents of gastrodin and parishins as indexes,chemical constituents difference in Gastrodiae Rhizoma between traditional processing and integration processing was compared,effects of Gastrodiae Rhizoma on eclampsia model induced by pentylenetetrazole were observed to compare products with different processing technology. Contents of gastrodin,parishin A,parishin B,Parishin C and parishin E in products of integration processing were 0. 79%,2. 04%,0. 91%,0. 23% and0. 57%,they were 0. 39%,1. 12%,0. 64%,0. 15% and 0. 54% in products of traditional processing. The anti-eclampsia effect of Gastrodiae Rhizoma produced with integrated processing technology was better thantraditional processing technology.
    CONCLUSIONS:
    Compared with the traditional processing technology, the integrated processing technology is better in guaranteeing the quality of pieces,reducing the cost of production and increasing the production efficiency.