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    Acteoside
    Information
    CAS No. 61276-17-3 Price $90 / 20mg
    Catalog No.CFN97048Purity>=98%
    Molecular Weight624.6 Type of CompoundPhenylpropanoids
    FormulaC29H36O15Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Acteoside Description
    Source: The herbs of Cistanche deserticola Y.C. Ma
    Biological Activity or Inhibitors: 1. Acteoside has antimicrobial activity.
    2. Acteoside has neuroprotective activity, can promote nerve growth factor and tropomycin receptor kinase A expression.
    3. Acteoside has anti-inflammatory activity, is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases.
    4. Acteoside has antioxidant activity, can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl‑2 ratio and downregulating the activity of procaspase‑3, as well as modulating the mitogen‑activated protein kinase signaling pathways.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.601 mL 8.0051 mL 16.0102 mL 32.0205 mL 40.0256 mL
    5 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    10 mM 0.1601 mL 0.8005 mL 1.601 mL 3.202 mL 4.0026 mL
    50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Acteoside References Information
    Citation [1]

    Int Immunopharmacol. 2015 May;26(1):23-9.

    Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2.[Pubmed: 25773666]
    Acteoside (verbascoside) is extensively distributed in Abeliophyllum distichum and has antimicrobial and anti-inflammatory properties. Thymic stromal lymphopoietin (TSLP) has a pivotal function in the pathogeneses of inflammatory diseases through increasing the mast cell proliferation via the activation of murine double minute 2 (MDM2). Here, we investigate whether Acteoside attenuates the MDM2 expression in a TSLP-stimulated human mast cell line (HMC-1 cells). In these cells, TSLP induced the up-regulation of MDM2 and the down-regulation of p53; however, in the TSLP-stimulated HMC-1 cells, the Acteoside down-regulated the MDM2 and up-regulated the p53. Increases in the phosphorylation of the single transducer and activation of transcription 6 and 5 via TSLP are decreased by Acteoside. The interleukin (IL)-13 (a mast cell growth factor), IL-6, tumor necrosis factor-α, and IL-1β levels are significantly reduced by the Acteoside in the TSLP-stimulated HMC-1 cells, and the Acteoside significantly induces the activation of caspase-3, the cleavage of poly-ADP-ribose polymerase, and the reduction of the procaspase-3 and Bcl2. Furthermore, the mRNA expressions of the TSLP receptor and IL-7 receptor that increase due to TSLP are reduced by the Acteoside. In conclusion, these results indicate that Acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases.
    Citation [2]

    Phytother Res. 2015 Apr 21.

    Memory Enhancement of Acteoside (Verbascoside) in a Senescent Mice Model Induced by a Combination of d-gal and AlCl3.[Pubmed: 25900014]
    Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which is used for its neuroprotective and memory enhancement properties. We have investigated the effects of Acteoside using a senescent mouse model induced by a combination of chronic intraperitoneal administration of d-gal (60 mg/kg/day) and oral administration AlCl3 (5 mg/kg/day) once daily for 90 days. After 60 days, Acteoside (30, 60, and 120 mg/kg/day) was orally administered once daily for 30 days. The memory enhancing effects of Acteoside were evaluated using the Morris water maze test. The results showed that 30-120 mg/kg/day of Acteoside reduced the escape latency in finding the platform, and increased the number of crossings of the platform. A 30-120 mg/kg/day of Acteoside increased significantly the expression of nerve growth factor and tropomycin receptor kinase A mRNA and protein in the hippocampus, measured using real-time RT-PCR, immunohistochemical analysis, and western blotting. These results support the use of C. deserticola for memory enhancement and indicate that the effects of Acteoside are induced via promotion of nerve growth factor and tropomycin receptor kinase A expression.
    Citation [3]

    Phytother Res. 2015 Apr 21.

    The Mechanism of Memory Enhancement of Acteoside (Verbascoside) in the Senescent Mouse Model Induced by a Combination of d-gal and AlCl3.[Pubmed: 25900087]
    Acteoside (verbsacoside), one of the main active phenylethanoid glycosides from Cistanche deserticola, is known to have antioxidant and neuroprotective activity, and herbs containing it are used to enhance memory. However, there is relatively little direct experimental evidence to support the use of Acteoside in Alzheimer's disease (AD). The purpose of this study was to elucidate the effects of Acteoside in improving learning and memory, using a mouse model of senescence induced by a combination of d-galactose and AlCl3 , and investigate its potential mechanisms compared with the positive controls vitamin E and piracetam. Acteoside was administered intragastrically at doses of 30, 60 and 120 mg/kg/day for 30 days after AD was induced. Memory function was evaluated using a step-down test. The number of neuron was analysed by haematoxylin and eosin staining and the number of Nissl bodies by Nissl staining. The expression of caspase-3 protein in hippocampus was detected by immunohistochemistry and western blot. Nitric oxide and total nitric oxide synthase level in hippocampus were also assessed. Our results showed that the latency of step down was shortened in AD model mice and the number of errors decreased after treatment with all doses of Acteoside. Neurons and Nissl bodies in the hippocampus were increased significantly with higher doses (60 and 120 mg/kg/day) of Acteoside. The content of nitric oxide, the activity of nitric oxide synthase and the expression of caspase-3 protein were decreased by 120 mg/kg/day Acteoside compared with that of the AD model group. Our results support the results obtained previously using the Morris maze test in the same mouse model of senescence, and the use of traditional medicinal herbs containing Acteoside for neuroprotection and memory loss.
    Citation [4]

    Mol Med Rep. 2015 Apr 16.

    Protective effects of acteoside against X‑ray‑induced damage in human skin fibroblasts.[Pubmed: 25892089]
    To investigate the protective effects of Acteoside against apoptosis induced by X‑ray radiation in human skin fibroblasts (HSFs), the cells were divided into the following groups: Control group; X‑ray radiation group; Acteoside group, in which the confluent cells were preincubated with 50 µg/ml Acteoside for 2 h followed by radiation; and positive control group, in which the cells were preincubated with 50 µg/ml paeoniflorin followed by radiation. For the radiation, HSF cells preincubated with Acteoside or paeoniflorin were exposed to X‑ray beams at a dose‑rate of 3 Gy/min (16 Gy in total). Cell viability, apoptosis and intracellular alteration of redox were monitored by MTT and flow cytometry. Compared with the radiation group, the number of cells arrested at the G0/G1 phase was significantly reduced in the Acteoside and paeoniflorin groups, respectively (P<0.05). X‑ray radiation induced marked apoptosis in HSF cells and Acteoside reversed this effect. Compared with the radiation group, the generation of intracellular reactive oxygen species (ROS) was abrogated by pre‑incubation with Acteoside or paeoniflorin (P<0.05). In addition, the upregulation of pro‑caspase‑3 induced by radiation was reversed by Acteoside or paeoniflorin. Radiation could induce upregulation of Bax and downregulation of Bcl‑2; however, it was reversed completely after administration of Acteoside or paeoniflorin. Furthermore, the enhanced expression of ERK and JNK induced by radiation was reversed by Acteoside or paeoniflorin. Acteoside could protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl‑2 ratio and downregulating the activity of procaspase‑3, as well as modulating the mitogen‑activated protein kinase signaling pathways.