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    Agrocybenine
    Information
    CAS No. 178764-92-6 Price
    Catalog No.CFN97881Purity>=98%
    Molecular Weight206.3Type of CompoundAlkaloids
    FormulaC12H18N2OPhysical DescriptionYellow Powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Alkaloids Compound Library
  • Biological Activity
    Description: Standard reference
    In vitro:
    Phytochemistry Letters, 2017 , 19 :168-171.
    Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity[Reference: WebLink]

    METHODS AND RESULTS:
    Two new alkaloids, nigellisoquinomine (1) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine (2) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, Agrocybenine (3) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one (4), were isolated from the seeds of Nigella glandulifera Freyn. Their structures were identified by extensive NMR and HR-ESIMS analysis.
    CONCLUSIONS:
    Compound 1 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 3.65 ± 0.08 uM.
    Agrocybenine Description
    Source: The herbs of Alstonia yunnanensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

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    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

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    IF=14.548(2019)

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    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8473 mL 24.2365 mL 48.4731 mL 96.9462 mL 121.1827 mL
    5 mM 0.9695 mL 4.8473 mL 9.6946 mL 19.3892 mL 24.2365 mL
    10 mM 0.4847 mL 2.4237 mL 4.8473 mL 9.6946 mL 12.1183 mL
    50 mM 0.0969 mL 0.4847 mL 0.9695 mL 1.9389 mL 2.4237 mL
    100 mM 0.0485 mL 0.2424 mL 0.4847 mL 0.9695 mL 1.2118 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Tetrahedron Letters.1996 June 24;37(36):4549–4550.
    Agrocybenine, novel class alkaloid from the Korean mushroom Agrocybe cylindracea.[Reference: WebLink]

    METHODS AND RESULTS:
    A new type alkaloid Agrocybenine was isolated from mushroom Agrocybe cylindracea. The structure of Agrocybenine was elucidated by spectroscopic methods, especially 15N-NMR studies using pulsed field gradient(PFG)-HMBC and HMQC techniques.