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    Epimedin B
    Information
    CAS No. 110623-73-9 Price $128 / 20mg
    Catalog No.CFN99940Purity>=98%
    Molecular Weight808.78Type of CompoundFlavonoids
    FormulaC38H48O19Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Epimedin A,epimendin B, epimendin C, icariin and baohuoside are flavonoids, main active ingredient in Epimedium, have clear anti-osteoporosis effect, the accumulation of epimedins A, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress.
    In vitro:
    Acta Physiol Plant, 2013, 35(11):3271-5.
    Light stress suppresses the accumulation of epimedins A, B, C, and icariin in Epimedium, a traditional medicinal plant.[Reference: WebLink]
    Epimedium is well-known in China and East Asia due to high content of flavonoid derivatives, including icariin, epimedin A, Epimedin B, and epimedin C, hereafter designated as bioactive components, which have been extensively utilized to cure many diseases. So far, the molecular mechanism of the bioactive components biosynthesis remains unclear.
    METHODS AND RESULTS:
    In the present study, the effect of light stress (24 h illumination) on the accumulation of bioactive components and the expression of flavonoid genes in Epimedium was investigated. Under light stress, the structural genes CHS1, CHI1, F3H, FLS, DFR1, DFR2, and ANS were remarkably up-regulated while CHS2 and F3′H were significantly down-regulated. For transcription factors, the expression of Epimedium MYB7 and TT8 were increased while Epimedium GL3, MYBF, and TTG1 expression were depressed. Additionally, the content of bioactive components was significantly decreased under light stress.
    CONCLUSIONS:
    Our results suggested that the decrease of bioactive compounds may be attributed to transcripts of late genes (DFRs and ANS) increased to a higher level than that of early genes (FLS and CHS1).
    Epimedin B Description
    Source: The herbs of Epimedium brevicornum Maxim
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    PMID: 29230013

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    doi: 10.3390/molecules22111829.

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    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2364 mL 6.1822 mL 12.3643 mL 24.7286 mL 30.9108 mL
    5 mM 0.2473 mL 1.2364 mL 2.4729 mL 4.9457 mL 6.1822 mL
    10 mM 0.1236 mL 0.6182 mL 1.2364 mL 2.4729 mL 3.0911 mL
    50 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    100 mM 0.0124 mL 0.0618 mL 0.1236 mL 0.2473 mL 0.3091 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    National Symposium on Chinese medicine and natural medicine. 2014.
    Study on Different Factors Affecting the Bionic Enzymatic Hydrolysis of Icariin,Epimedin A,Epimendin B,Epimendin C and Eplmedium Flavonolds.[Reference: WebLink]
    Flavonoids were the main active ingredient in Epimedium and mainly included icariin,epimedin A,epimendin B,epimendin C and baohuoside.Modern pharmacological studies have shown that Epimedium flavone had clear anti-osteoporosis effect. In order to obtain an improved absorption,transformation to secondary glycosides by intestinal enzymes and intestinal bacteria is necessary after the oral administration[1].However,intestinal enzymes and intestinal bacteria were unstable and could be affected by race,age,diet and medication[2].To screen effective and safe hydrolase in vitro and add it to epimedium flavone preparation could promote oral absorption of epimedium flavonoids,increase its bioavailability and improve its efficacy.
    METHODS AND RESULTS:
    This study aims to screen effective and safe hydrolase,investgate different factors which affect the bionic enzymatic hydrolysis of epimedium flavonoids and optimize the reaction conditions for building a novel bionic enzymolysis drug delivery system.To simulate the environment in vivo,37 °C was set as the temperature and artificial intestinal juice and gastric juice was selected as the buffer solutions.Taking the conversion of epimedium flavonoids as index,the effects of the kinds of enzyme,the ratio of enzyme and substrate,substrate concentration,reaction time,pancreatin were investigated.
    CONCLUSIONS:
    The results show the conversion of epimedium flavonoids was highest and their enzymolysis products was accordant with the intestinal metabolites by using snailase in artificial intestinal juice.Moreover,the main flavonoids could be completely transformed into the secondary glycoside or aglycone during 2~6 h.
    Structure Identification:
    Nat Prod Res. 2015;29(2):185-8.
    Simultaneous enrichment and separation of flavonoids from Herba Epimedii by macroporous resins coupled with preparative chromatographic method.[Pubmed: 25277166]

    METHODS AND RESULTS:
    An efficient, feasible enrichment and separation method of epimedin A,Epimedin B,epimedin C and icariin from Herba Epimedii was developed by the combination of microwave-assisted extraction, macroporous resins and preparative HPLC. WDX-5 macroporous resin shows better recoveries at 96.2%, 97.0%, 98.2% and 97.1% for epimedins A, B, C and icariin than other macroporous resins used in the experiments. As a result, epimedins A (5.1 mg),Epimedin B (15.3 mg),epimedin C (7.6 mg) and icariin (14.3 mg) were obtained from 6.0 g crude Herba Epimedii with the recoveries at 70.8%, 68.9%, 66.7% and 95.3%, respectively.
    CONCLUSIONS:
    The method developed in this study may provide scientific references for the enrichment and separation of flavonoids from Herba Epimedii.