Science | Nature | Cell | View More
Natural Products
Aphadilactone B
Aphadilactone B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Aphadilactone B
Price:
CAS No.: 1522004-68-7
Catalog No.: CFN89368
Molecular Formula: C40H52O8
Molecular Weight: 660.83 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Oil
Source: The leaves of Aphanamixis grandifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Guangzhou Institutes of Biomedi... (China)
  • University of Perugia (Italy)
  • Kazusa DNA Research Institute (Japan)
  • Gyeongsang National University (Korea)
  • National Chung Hsing University (Taiwan)
  • Mahidol University (Thailand)
  • Srinakharinwirot University (Thailand)
  • Medical University of Gdansk (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidade do Porto (Portugal)
  • Indian Institute of Science (India)
  • More...
Package
Featured Products
Ellagic acid

Catalog No: CFN98716
CAS No: 476-66-4
Price: $30/20mg
Platycoside E

Catalog No: CFN90786
CAS No: 237068-41-6
Price: $ / mg
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Astin C

Catalog No: CFN95189
CAS No: 148057-23-2
Price: $318/10mg
Soybean phospholipid

Catalog No: CFN93800
CAS No: 8002-43-5
Price: $30/20mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
(+)-Syringaresinol

Catalog No: CFN89209
CAS No: 21453-69-0
Price: $ / mg
Linarin

Catalog No: CFN98738
CAS No: 480-36-4
Price: $40/20mg
Clerosterol

Catalog No: CFN90787
CAS No: 2364-23-0
Price: $ / mg
Gypenoside L

Catalog No: CFN91854
CAS No: 94987-09-4
Price: $268/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Aphadilactone B shows significant antimalarial activity with the IC50 value of 1350 ± 150 nM.
Targets: Antifection
In vitro:
J Org Chem. 2014 Jan 17;79(2):599-607.
Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant.[Pubmed: 24344740 ]

METHODS AND RESULTS:
Aphadilactone A, Aphadilactone B, Aphadilactone C, Aphadilactone D (1-4), four diastereoisomers possessing an unprecedented carbon skeleton, were isolated from the Meliaceae plant Aphanamixis grandifolia. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chemical degradation, fragment synthesis, experimental CD spectra, and ECD calculations.
CONCLUSIONS:
Aphadilactone C (3) with the 5S,11S,5'S,11'S configuration showed potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 μM, selectivity index > 217) and is the strongest natural DGAT-1 inhibitor discovered to date. In addition, compounds 1-4 showed significant antimalarial activities with IC50 values of 190 ± 60, 1350 ± 150, 170 ± 10, and 120 ± 50 nM, respectively.
Aphadilactone B Description
Source: The leaves of Aphanamixis grandifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Naringin 4'-glucoside

Catalog No: CFN95014
CAS No: 17257-21-5
Price: $338/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
Iristectorin A

Catalog No: CFN95037
CAS No: 37744-61-9
Price: $318/20mg
Iristectorin A-6''-O-glucoside

Catalog No: CFN95597
CAS No: 86849-71-0
Price: $413/5mg
Lariciresinol 4-O-glucoside

Catalog No: CFN95389
CAS No: 143663-00-7
Price: $318/5mg
erythro-Austrobailignan-6

Catalog No: CFN95501
CAS No: 114127-24-1
Price: $318/10mg
Cagayanin

Catalog No: CFN95480
CAS No: 99096-51-2
Price: $318/20mg
Lariciresinol 4'-O-glucoside

Catalog No: CFN95400
CAS No: 107110-16-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5132 mL 7.5662 mL 15.1325 mL 30.265 mL 37.8312 mL
5 mM 0.3026 mL 1.5132 mL 3.0265 mL 6.053 mL 7.5662 mL
10 mM 0.1513 mL 0.7566 mL 1.5132 mL 3.0265 mL 3.7831 mL
50 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.6053 mL 0.7566 mL
100 mM 0.0151 mL 0.0757 mL 0.1513 mL 0.3026 mL 0.3783 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Ellagic acid

Catalog No: CFN98716
CAS No: 476-66-4
Price: $30/20mg
Platycoside E

Catalog No: CFN90786
CAS No: 237068-41-6
Price: $ / mg
Kaempferol-3-O-(2',6'-di-O-trans-p...

Catalog No: CFN92386
CAS No: 121651-61-4
Price: $ / mg
Astin C

Catalog No: CFN95189
CAS No: 148057-23-2
Price: $318/10mg
Soybean phospholipid

Catalog No: CFN93800
CAS No: 8002-43-5
Price: $30/20mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
(+)-Syringaresinol

Catalog No: CFN89209
CAS No: 21453-69-0
Price: $ / mg
Linarin

Catalog No: CFN98738
CAS No: 480-36-4
Price: $40/20mg
Clerosterol

Catalog No: CFN90787
CAS No: 2364-23-0
Price: $ / mg
Gypenoside L

Catalog No: CFN91854
CAS No: 94987-09-4
Price: $268/5mg
Tags: buy Aphadilactone B | Aphadilactone B supplier | purchase Aphadilactone B | Aphadilactone B cost | Aphadilactone B manufacturer | order Aphadilactone B | Aphadilactone B distributor