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    Boscialin
    Information
    CAS No. 129277-03-8 Price
    Catalog No.CFN89022Purity>=98%
    Molecular Weight226.31Type of CompoundSesquiterpenoids
    FormulaC13H22O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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  • Biological Activity
    Description: Boscialin can inhibit signal transducer and activator of transcription 1 translocation at a concentration of 10 uM.
    Boscialin Description
    Source: The leaves of Tripterygium wilfordii Hook.f.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4187 mL 22.0936 mL 44.1872 mL 88.3744 mL 110.4679 mL
    5 mM 0.8837 mL 4.4187 mL 8.8374 mL 17.6749 mL 22.0936 mL
    10 mM 0.4419 mL 2.2094 mL 4.4187 mL 8.8374 mL 11.0468 mL
    50 mM 0.0884 mL 0.4419 mL 0.8837 mL 1.7675 mL 2.2094 mL
    100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8837 mL 1.1047 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Asian Nat Prod Res. 2015;17(6):615-24.
    Wilfordonols A-D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii.[Pubmed: 26096035 ]

    METHODS AND RESULTS:
    Four new norsesquiterpenes wilfordonols A-D (1-4), along with three known compounds, sarmentol B (5), Boscialin (6), and (+)-loliolide (7), were isolated from the leaves of Tripterygium wilfordii Hook.f.. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of the compounds was confirmed by CD and modified Mosher's method.
    CONCLUSIONS:
    At a concentration of 10 μM, compounds 4, 6, and 7 inhibited signal transducer and activator of transcription 1 translocation by 34.27 ± 1.02%, 48.93 ± 1.76%, and 70.31 ± 2.20%, respectively.