Camellianin A | CAS:109232-77-1 | Manufacturer ChemFaces

Camellianin A

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Description:

Camellianin A has anticancer activity, it can inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. Camellianin A also shows angiotensin converting enzyme (ACE) inhibitory activity.

Targets:

ACEI

In vitro:

Molecules. 2010 May 28;15(6):3878-86.

Anti-proliferative effect of camellianin A in Adinandra nitida leaves and its apoptotic induction in human Hep G2 and MCF-7 cells.[Pubmed: 20657414 ]

Leaves of Adinandra nitida constitute a kind of flavonoid-rich plant food.
METHODS AND RESULTS:
In this study, Camellianin A, the main flavonoid in the leaves of Adinandra nitida,was prepared and identified by high performance liquid chromatography-photodiode array detector-electrospray ionization mass spectrometry (HPLC-PDA-ESI/MS). In the anticancer assay, it was found Camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treated by Camellianin A, phosphatidylserine of Hep G2 and MCF-7 cells could translocate significantly to the surface of the membrane. The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed.
CONCLUSIONS:
It was concluded that Camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis.

Camellianin A Description

Source:	The leaves of Adinandra nitida Merr. ex. H.L. Li .
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.

PMID: 29328914

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.

PMID: 29149595

Scientific Reports 2017 Dec 11;7(1):17332.
doi: 10.1038/s41598-017-17427-6.

PMID: 29230013

Molecules. 2017 Oct 27;22(11). pii: E1829.
doi: 10.3390/molecules22111829.

PMID: 29077044

J Cell Biochem. 2018 Feb;119(2):2231-2239.
doi: 10.1002/jcb.26385.

PMID: 28857247

Phytomedicine. 2018 Feb 1;40:37-47.
doi:10.1016/j.phymed.2017.12.030

PMID: 29496173

Kinase Assay:

Pharm Biol. 2010 Dec;48(12):1432-8.

Antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of ethanol extract and pure flavonoids from Adinandra nitida leaves.[Pubmed: 20738217]

Adinandra nitida Merr. ex. H.L. Li (Theaceae) is an indigenous plant in south China. Its leaves have been reported to have many curative effects such as reducing blood pressure, as well as antibacterial, antioxidant, and analgesic properties, which could be used in foods and medicines. The antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of the main flavonoids and ethanol extract (EE) of A. nitida leaves were investigated for the first time.
METHODS AND RESULTS:
The main flavonoids of A. nitida leaves (Camellianin A, camellianin B) were prepared and their contents in EE were determined by HPLC. The antioxidant activities of the samples were measured by DPPH radical scavenging assay and Rancimat test. The ACE inhibitory activities of the samples were carried out by using an assay kit with hippuryl-glycyl-glycine as substrate. The contents of Camellianin A, camellianin B and apigenin in EE were determined as 41.98, 2.67, and 1.73%, respectively. The antioxidant activities of the flavonoids were far lower than that of EE in DPPH radical scavenging and Rancimat assays. However, the ACE-inhibitory activities of Camellianin A, camellianin B and apigenin were higher than that of EE.
CONCLUSIONS:
The flavonoid content of EE was more than 45%. The high activities of EE in DPPH scavenging and Rancimat assay could be mainly attributed to compounds other than flavonoids. However, the ACE-inhibitory activity of EE could be mainly attributed to the presence of the flavonoids.

CAS No.	109232-77-1	Price	$268 / 5mg
Catalog No.	CFN90992	Purity	>=98%
Molecular Weight	620.56	Type of Compound	Flavonoids
Formula	C₂₉H₃₂O₁₅	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6114 mL	8.0572 mL	16.1145 mL	32.229 mL	40.2862 mL
5 mM	0.3223 mL	1.6114 mL	3.2229 mL	6.4458 mL	8.0572 mL
10 mM	0.1611 mL	0.8057 mL	1.6114 mL	3.2229 mL	4.0286 mL
50 mM	0.0322 mL	0.1611 mL	0.3223 mL	0.6446 mL	0.8057 mL
100 mM	0.0161 mL	0.0806 mL	0.1611 mL	0.3223 mL	0.4029 mL

CFN90224	Ligustroflavone	260413-62-5	724.67	C₃₃H₄₀O₁₈
CFN90671	Apigenin 7-O-(2G-rhamnosyl)gentiobioside	174284-20-9	740.67	C₃₃H₄₀O₁₉
CFN97327	Anisofolin A	83529-71-9	724.7	C₃₉H₃₂O₁₄
CFN95082	Scutellarein-7-O-glucoside	26046-94-6	448.4	C₂₁H₂₀O₁₁
CFN99112	Scutellarin	27740-01-8	462.37	C₂₁H₁₈O₁₂
CFN90695	Scutellarin methylester	119262-68-9	476.39	C₂₂H₂₀O₁₂
CFN90344	Homoplantaginin	17680-84-1	462.40	C₂₂H₂₂O₁₁
CFN90892	Hispidulin 7-O-neohesperidoside	156186-00-4	608.6	C₂₈H₃₂O₁₅
CFN96507	Cirsimarin	13020-19-4	476.43	C₂₃H₂₄O₁₁
CFN97699	5,8,4'-Trihydroxy-7-methoxyflavone 8-O-glucoside	710952-13-9	462.41	C₂₂H₂₂O₁₁