|Description:|| 1. Caulilexin C shows inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 mug/ml.|
|Source:||The herbs of Isatis idigotica|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||5.3706 mL||26.8528 mL||53.7057 mL||107.4114 mL||134.2642 mL|
|5 mM||1.0741 mL||5.3706 mL||10.7411 mL||21.4823 mL||26.8528 mL|
|10 mM||0.5371 mL||2.6853 mL||5.3706 mL||10.7411 mL||13.4264 mL|
|50 mM||0.1074 mL||0.5371 mL||1.0741 mL||2.1482 mL||2.6853 mL|
|100 mM||0.0537 mL||0.2685 mL||0.5371 mL||1.0741 mL||1.3426 mL|
Phytochemistry. 2011 Dec;72(18):2308-16.
|Interaction of cruciferous phytoanticipins with plant fungal pathogens: indole glucosinolates are not metabolized but the corresponding desulfo-derivatives and nitriles are.[Pubmed: 21920565]|
|While glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin were not metabolized by the pathogenic fungi Alternaria brassicicola, Rhizoctonia solani and Sclerotinia sclerotiorum, the corresponding desulfo-derivatives were metabolized to indolyl-3-acetonitrile, Caulilexin C (1-methoxyindolyl-3-acetonitrile) and arvelexin (4-methoxyindolyl-3-acetonitrile) by R. solani and S. sclerotiorum, but not by A. brassicicola. That is, desulfo-glucosinolates were metabolized by two non-host-selective pathogens, but not by a host-selective. Indolyl-3-acetonitrile, Caulilexin C and arvelexin were metabolized to the corresponding indole-3-carboxylic acids.|
Tetrahedron Letters, 2008 , 51 (1) :65-69.
|Development of Biologically Active Compounds from Edible Plant Sources XXII. Isolation of Indoles from the Roots of Brassica campestris ssp rapa and their hACAT Inhibitory Activity[Reference: WebLink]|
|The roots of Brassica campestris ssp rapa were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. From the EtOAc fraction, three compounds were isolated through the repeated silica gel and octadecyl silica gel (ODS) column chromatography. From the results of spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as Caulilexin C (1), indoleacetonitrile (2) and arvelexin (3). The arvelexin (3) has been isolated from this plant for the first time. Compounds 1, 2 and 3 showed inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) by 54.6 +/- 6.0%, 69.2 +/- 4.7% and 68.6 +/- 3.7%, and on human Acyl CoA: cholesterol transferase 2 (hACAT2) by 4.8 +/- 13.4%, 45.6 +/- 4.8%, and 39.5 +/- 4.3%, respectively, at 100 mu g/ml.|