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    Lobetyolin
    Information
    CAS No. 136085-37-5 Price $168 / 20mg
    Catalog No.CFN99104Purity>=98%
    Molecular Weight396.43Type of CompoundMiscellaneous
    FormulaC20H28O8Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Lobetyolin has a protective role in gastric mucosa injury, and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF. Lobetyolin inhibits the gene expression of MUC5AC mucin induced by PMA.
    Targets: EGFR
    In vitro:
    Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.
    Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells.[Pubmed: 25473407]
    In this study, we investigated whether Lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells.
    METHODS AND RESULTS:
    Confluent NCI-H292 cells were pretreated with Lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; Lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; Lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion.
    CONCLUSIONS:
    These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.
    In vivo:
    Journal of Emergency in Traditional Chinese Medicine, 2008, 17(7):963-4.
    Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats[Reference: WebLink]
    To study the protective effect of Lobetyolin on gastric mucosa of experimental gastric ulcer induced by ethanol in rats.
    METHODS AND RESULTS:
    The gastric ulcer model was established in rats by inducing ethanol.The index of ulcer was measured;the levels of Gas and 6-K-PGF1αwere examined by the method of radioimmunity;the level of EGF was measured by ELISA.As compared with model group,in Lobetyolin small dose group,the index of ulcer was markedly decreased,the level of Gas was decreased while the level of 6-K-PGF1αwas increased.In the degree,the level of EGF was increased.
    CONCLUSIONS:
    Lobetyolin has a protective role in gastric mucosa injury,and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF.
    Lobetyolin Description
    Source: The roots of Codonopsis pilosula.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5225 mL 12.6126 mL 25.2251 mL 50.4503 mL 63.0628 mL
    5 mM 0.5045 mL 2.5225 mL 5.045 mL 10.0901 mL 12.6126 mL
    10 mM 0.2523 mL 1.2613 mL 2.5225 mL 5.045 mL 6.3063 mL
    50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.009 mL 1.2613 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5045 mL 0.6306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhong Yao Cai. 2011 Apr;34(4):546-8.
    Studies on the chemical constituents of Codonopsis pilosula.[Pubmed: 21809539]
    To study the chemical constituents of Codonopsis pilosula.
    METHODS AND RESULTS:
    The compounds were isolated and purified by column chromatography and their structures were elucidated through spectroscopic techniques (NMR) and physicochemical properties. The compounds were isolated as hesperidin(I), n-hexyl beta-sophoroside(II), atractylenolide III (III), Lobetyolin(IV), Lobetyolinin(V), taraxerol(VI), taraxeryl acetate(VII), alpha-spinasterol(VIII),9,10,13-trihydroxy-(E)-11-octadecenoic acid (IX),beta-sitosterol(X),beta-daucosterol(XI)and sugar(XII).
    CONCLUSIONS:
    Compounds 1 -2 and 9 are isolated from this plant for the first time.