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    Chlorogenic acid
    Information
    CAS No. 327-97-9 Price $50 / 20mg
    Catalog No.CFN99116Purity>=98%
    Molecular Weight354.31Type of CompoundPhenylpropanoids
    FormulaC16H18O9Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Chlorogenic acid Description
    Source: The bark of Eucommia ulmoides Oliv.
    Biological Activity or Inhibitors: 1. Chlorogenic acid exhibits remarkable antioxidative activity.
    2. Chlorogenic acid has a wide range of antibacterial action.
    3. Chlorogenic acid is an important intermediate in lignin biosynthesis.
    4. Chlorogenic acid inhibits the inflammatory reaction in HSE via the suppression of TLR2/TLR9-Myd88 signaling pathways.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8224 mL 14.1119 mL 28.2239 mL 56.4477 mL 70.5597 mL
    5 mM 0.5645 mL 2.8224 mL 5.6448 mL 11.2895 mL 14.1119 mL
    10 mM 0.2822 mL 1.4112 mL 2.8224 mL 5.6448 mL 7.056 mL
    50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.129 mL 1.4112 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5645 mL 0.7056 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Chlorogenic acid References Information
    Citation [1]

    Life Sci. 2015 Mar 2. pii: S0024-3205(15)00105-8.

    Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia.[Pubmed: 25744394]
    Chlorogenic acid inhibits the inflammatory reaction in HSE via the suppression of TLR2/TLR9-Myd88 signaling pathways. Chlorogenic acid may serve as an anti-inflammatory agent and provide a new strategy for treating HSE.
    Citation [2]

    Anticancer Drugs. 2015 Feb 24.

    Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases.[Pubmed: 25714249]
    Combined with our results, this indicates that the combination of 5-fluorouracil and Chlorogenic acid leads to the inactivation of ERK through the overproduction of ROS. This mediates the enhancement of 5-fluorouracil-induced inhibition of hepatocellular carcinoma cells' proliferation, that is, Chlorogenic acid sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by the suppression of ERK activation through the overproduction of ROS. Chlorogenic acid has shown potential as a chemosensitizer of 5-fluorouracil chemotherapy in hepatocellular carcinoma.
    Citation [3]

    Int J Clin Exp Pathol. 2014 Dec 1;7(12):8797-801.

    Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes.[Pubmed: 25674248]
    We investigated the anti-inflammatory properties of Chlorogenic acid (CGA) in interleukin-1β-induced chondrocytes. The nitric oxide (NO) and prostaglandin E2 (PGE2) were detected by Griess and Enzyme-linked immunosorbent assay (ELISA) respectively. Quantitative real-time PCR and western blot were performed to measure the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. Our results indicate that Chlorogenic acid inhibited the production of NO and PGE2 as well as the expression of iNOS and COX-2 in chondrocytes. Our data suggest that Chlorogenic acid possess potential value in the treatment of OA.