ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $35.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Drug Target.2016, 24:1-28Food and Bioprocess Technology...2017...Org Biomol Chem.2017, 15(31):6483-6492Int J Mol Sci.2017, 18(12)Research on Crops.2017, 18(2)Molecules.2017, 22(3)Br J Pharmacol.2018, 175(6):902-923Int J Mol Sci.2018, 19(9):E2681
Evid Based Complement Alternat Me...2018...Biol Pharm Bull.2018, 41(11):1685-1693The Japan Society for Analytical ...2018...J Nat Med.2018, 72(3):734-744Cancer Manag Res.2019, 11:483-500Postharvest Biol Tec2019, 149:18-26Asian Pac J Cancer Prev....2019...Molecules.2019, 24(2):329
J Enzyme Inhib Med Chem....2019...Cell Physiol Biochem....2019...Journal of Functional Foods...2019...J Funct Foods2019, 54:449-456Chemistry of Natural Compounds...2019...Planta Med.2019, 85(9-10):766-773Br J Pharmacol.2020, 10.1111
Our products had been exported to the following research institutions and universities, And still growing.
University of Wuerzburg (Germany)The Vancouver Prostate Centre (... (Canada)National Cancer Center Research... (Japan)Universidad de Ciencias y Artes... (Mexico)
Amity University (India)University of Hertfordshire (United Kingdom)Harvard University (USA)Chiang Mai University (Thailand)
Auburn University (USA)University of Dicle (Turkey)Worcester Polytechnic Institute (USA)
Related Screening Libraries
||Cimifugin evidently inhibits FITC-induced type 2 allergic contact dermatitis,and its mechanism might related to regulating the balance of Th1 /Th2 by inhibiting type 2 cytokines. Cimifugin displayed low to moderate inhibition towards AChE and BChE (3.12 and 21.63%, respectively) at 200 ug/mL. |
||IFN-γ | IL Receptor | AChR | BChR|
|Pharmacol. Clin. Chinese Mat. Med., 2014, 30(2):28-30. |
|Cimifugin inhibits allergic contact dermatitis by regulating type 2 cytokines.[Reference: WebLink]|
|This study was carried out to investigate the effective and mechanism of Cimifugin on type 2 allergic contact dermatitis induced by FITC. |
METHODS AND RESULTS:
The BALB /c mice were sensitized with FITC on days 1 and 2,on the shaved abdomen skin. On day 6,the animals were challenged on their right ears with FITC. Simultaneously,the mice were administered Cimifugin from day 1 to day 5. On day 7,ear swelling was measured and the infiltration of lymphocytic was investigated by hematoxylin and eosin( HE) staining. The levels of IL-4,IL-9,IL-13 and IFN-γ were quantified by ELISA and BCA. The results suggested that mouse ear swelling was dramatically inhibited by25 mg /kg,50 mg /kg Cimifugin. Histopathological results indicated that mice given Cimifugin has significant improvement on local tissue fluid exudation,congestion,and lymphocytic infiltration was remarkably reduced by Cimifugin. At the same time type 2 cytokines IL-4,IL-9,IL-13in the mouse ear tissue homogenate were obviously reduced by Cimifugin,while no significant changes with type 1 cytokines IFN-γ.
Cimifugin evidently inhibited FITC-induced type 2 allergic contact dermatitis,and its mechanism might related to regulating the balance of Th1 /Th2 by inhibiting type 2 cytokines.
||The roots of Saposhnikovia divaricata (Turcz.) Schischk.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Natural Product Communications, 2016, 11(8). |
|Development of an Efficient Protocol for Cimifugin Isolation from Peucedanum schottii and Evaluation of Enzyme Inhibitory Activity.[Reference: WebLink]|
METHODS AND RESULTS:
The dichloromethane extract of the fruits of Peucedanum schotti Besser ex DC. (Apiaceae) was subjected to high-performance counter-current chromatography (HPCCC) for the efficient and fast separation (30 min) and subsequent isolation of Cimifugin using ethyl acetate: water (1:1 v/v, K = 1.01) system.
Separation was further optimized on analytical scale and then easy up-scaled to semipreparative conditions. A total of 135 mg of Cimifugin (96.5% purity) was purified from 1.2 g of the dichloromethane extract (11.25% yield). Cimifugin was isolated for the first time from P. schotti and characterized by NMR spectroscopy. Further Cimifugin, along with the crude extract were evaluated for their inhibitory potential against cholinesterases (acetylcholinesterase - AChE and butyrylcholinesterase - BChE) and tyrosinase (TYR), key enzymes for the treatment of some neurodegenerative diseases, i.e. Alzheimer’s and Parkinson’s, using ELISA microtiter assays.
The crude extract exhibited a weak inhibitory activity against AChE, BChE, and TYR (4.19, 35.47, and 0% at 100 μg mL-1 and 10.26, 40.03, and 12.25% at 200 μg mL-1, respectively), while Cimifugin displayed low to moderate inhibition towards AChE and BChE (3.12 and 21.63%, respectively) at 200 μg mL-1.
| Biomed Chromatogr. 2012 Oct;26(10):1234-40. |
| Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats.[Pubmed: 22253022]|
|A sensitive and reliable liquid chromatography-mass spectrometry method has been developed and validated for simultaneous determination of Cimifugin and prim-O-glucosylCimifugin in rat plasma after oral administration of Radix Saposhnikoviae (RS) extract, prim-O-glucosylCimifugin monomer solution and Cimifugin monomer solution.
METHODS AND RESULTS:
Plasma samples were pretreated by protein precipitation with acetonitrile containing the internal standards puerarin and daidzein. LC separation was achieved on a Zorbax SB-C(18) column (150 × 4.6 mm i.d., 5 μm) with 0.1% formic acid in water and methanol by isocratic elution. The detection was carried out in select-ion-monitoring mode with a positive electrospray ionization interface. The fully validated method was successfully applied to the pharmacokinetic study of the analytes in rats. A bimodal phenomenon appeared in the concentration-time curve of prim-O-glucosylCimifugin and Cimifugin after oral administration of RS extract. Prim-O-glucosylCimifugin mainly transformed to Cimifugin when it was absorbed into blood. Both absorption and elimination of Cimifugin after oral administration of RS were longer than after administration of single Cimifugin.
The pharmacokinetic parameters (AUC(0-t) , AUC(0-∞) and t(1/2) ) of prim-O-glucosylCimifugin and Cimifugin by giving Cimifugin monomer solution, prim-O-glucosylCimifugin monomer solution and RS extract had significant differences (P < 0.05).