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    Pilosidine
    Pilosidine
    Information
    CAS No. 229971-57-7 Price $413 / 5mg
    Catalog No.CFN95110Purity>=98%
    Molecular Weight478.5Type of CompoundPhenols
    FormulaC23H26O11Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Pilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
    In vitro:
    Phytochemistry, 2000, 55(5):411-417.
    Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity[Pubmed: 11140602 ]

    METHODS AND RESULTS:
    From the rhizomes of Curculigo pilosa, two benzylbenzoate diglucosides, piloside A and piloside B, and a glucosyl-fused norlignan, Pilosidine, previously obtained only as the tetra-O-methyl derivative, were isolated.
    CONCLUSIONS:
    Pilosidine showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
    Pilosidine Description
    Source: The herbs of Curculigo capitulata
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0899 mL 10.4493 mL 20.8986 mL 41.7973 mL 52.2466 mL
    5 mM 0.418 mL 2.0899 mL 4.1797 mL 8.3595 mL 10.4493 mL
    10 mM 0.209 mL 1.0449 mL 2.0899 mL 4.1797 mL 5.2247 mL
    50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8359 mL 1.0449 mL
    100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Farmaco. 2001 May-Jul;56(5-7):353-6.
    Studies on vasoconstrictor activity of Curculigo pilosa extracts and of its isolated compounds.[Pubmed: 11482757]

    METHODS AND RESULTS:
    The Curculigo pilosa total extract, its butanolic fraction (0.5 microg-100 mg/kg) and the most active in vitro compound structurally similar to adrenaline, Pilosidine (10 ng-l mg/kg), caused a reversible and dose-dependent increase in blood pressure in anaesthetized rat. This hypertensive effect is partially reversed (90%) by the prior administration of phentolamine (1 mg/kg) and abolished by pre-treatment with phentolamine (1 mg/kg) and atenolol (100 microg/kg). Neither tachiphylaxis nor any toxic effects were observed.
    CONCLUSIONS:
    These experimental findings suggest an interaction between C. pilosa and the peripheral adrenergic system (particularly with alpha1 and beta1 receptors); the structure of the bioactive glucosides could be important in evoking this effect.