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    Clausine D
    Clausine D
    Information
    CAS No. 142846-95-5 Price
    Catalog No.CFN97821Purity>=98%
    Molecular Weight279.34Type of CompoundAlkaloids
    FormulaC18H17NO2Physical DescriptionYellow powder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Clausine D Description
    Source: The herbs of Clausena excavata
    Biological Activity or Inhibitors: 1. Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5799 mL 17.8993 mL 35.7987 mL 71.5973 mL 89.4967 mL
    5 mM 0.716 mL 3.5799 mL 7.1597 mL 14.3195 mL 17.8993 mL
    10 mM 0.358 mL 1.7899 mL 3.5799 mL 7.1597 mL 8.9497 mL
    50 mM 0.0716 mL 0.358 mL 0.716 mL 1.4319 mL 1.7899 mL
    100 mM 0.0358 mL 0.179 mL 0.358 mL 0.716 mL 0.895 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Clausine D References Information
    Citation [1]

    Biochim Biophys Acta. 1994 Sep 28;1201(1):1-6.

    Antiplatelet effects of clausine D isolated from Clausena excavata.[Pubmed: 7918571 ]
    Clausine D inhibited concentration-dependently the aggregation and release reaction of washed rabbit platelets induced by arachidonic acid and collagen, without affecting those induced by U46619, PAF and thrombin. The IC50 values of Clausine D on arachidonic acid- and collagen-induced platelet aggregation were calculated to be 9.0 +/- 1.1 and 58.9 +/- 0.9 microM, respectively. Thromboxane B2 and prostaglandin D2 formation in platelets caused by arachidonic acid were also suppressed. Clausine D inhibited increased intracellular concentration of calcium in platelets caused by arachidonic acid and collagen, and also abolished the generation of inositol monophosphate caused by arachidonic acid, but not that by collagen, U46619, PAF and thrombin. In human citrated platelet-rich plasma, Clausine D inhibited the secondary phase, but not the primary phase, of aggregation induced by epinephrine and ADP. These results indicate that the antiplatelet effect of Clausine D is due to inhibition of the formation of thromboxane A2.
    Citation [2]

    Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1069-71.

    Clausine D and -F, two new 4-prenylcarbazole alkaloids from Clausena excavata.[Pubmed: 1525939]
    Two new 4-prenylcarbazole alkaloids, Clausine D (1) and -F (3) were isolated from the stem bark of Clausena excavata. Their structures were elucidated by spectral methods. Both of Clausine D (1) and -F (3) showed significant antiplatelet aggregation activity.