|Description:||1. Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses.|
2. The absorption of columbianetin acetate is a passive diffusion process without pH-dependent.
|Targets:||Immunology & Inflammation related|
|Source:||The roots of Angelica biserrata|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.4686 mL||17.343 mL||34.6861 mL||69.3722 mL||86.7152 mL|
|5 mM||0.6937 mL||3.4686 mL||6.9372 mL||13.8744 mL||17.343 mL|
|10 mM||0.3469 mL||1.7343 mL||3.4686 mL||6.9372 mL||8.6715 mL|
|50 mM||0.0694 mL||0.3469 mL||0.6937 mL||1.3874 mL||1.7343 mL|
|100 mM||0.0347 mL||0.1734 mL||0.3469 mL||0.6937 mL||0.8672 mL|
Planta Med. 1995 Feb;61(1):2-8.
|Anti-inflammatory and analgesic activities from roots of Angelica pubescens.[Pubmed: 7700984]|
|Columbianadin, Columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated anti-inflammatory and analgesic activities at 10 mg/kg. However, only osthole and xanthotoxin revealed anti-inflammatory activity. Isoimperatorin only demonstrated an analgesic effect. These results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system.|
Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):392-8.
|Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model[Pubmed: 18405608]|
|Among the 6 coumarins, the P(app) values of umbelliferone, osthole, angelol-A and angelol-B from AP to BL side were identical with that of propranolol, and columbianadin and Columbianetin acetate lied between propranolol and atenolol.The absorption and transport of umbelliferone, osthole, columbianadin, Columbianetin acetate, angelol-A and angelol-B are passive diffusion as the dominating process in Caco-2 cell monolayer model. Umbelliferone, osthole, angelol-A and angelol-B are estimated to be highly absorbed compounds, and columbianadin and Columbianetin acetate are estimated to be moderately absorbed compounds. In the Caco-2 cells, osthol and columbianadin appear to accumulate, and Columbianetin acetate may be metabolized. The absorption and transport of angelol-B are not influenced by the change of pH and the presence of iodoacetamide or MK571.|