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    Natural Products
    Cornin
    Information
    CAS No. 548-37-8 Price $138 / 20mg
    Catalog No.CFN98160Purity>=98%
    Molecular Weight388.37Type of CompoundIridoids
    FormulaC17H24O10Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $49.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Deutsches Krebsforschungszentrum (Germany)
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  • Biological Activity
    Description: Verbenalin has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury and cerebral ischemia injury. Cornin induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis, it also has antimitotic action on dividing cell.
    Targets: PI3K | Akt | NOS | VEGFR | ROS
    In vitro:
    Acta Med Okayama. 1977 Jun;31(3):203-9.
    Purification and some characteristics of liver cytosol cornin, an antimitotic substance from rat liver cytosol.[Pubmed: 144419]
    Further purification and characterization are reported on rat cytosol Cornin (RLCC), an antimitotic substance.
    METHODS AND RESULTS:
    Fraction I (purified RLCC) was purified more than 10-fold from crude RLCC with Sephadex G-50 column chromatography and showed a remarkable inhibitory effect on division of inseminated sea urchin eggs and mouse fibroblast cells. Fraction I was observed as one spot, and the molecular weight was estimated to be about 25,000 by thin layer gel filtration. Fraction I contained protein (92%) and RNA (8%), but the antimitotic activity was scarcely affected by treatment by pancreatic RNase. The protein of Fraction I was separated into two bands by SDS-polyacrylamide gel electrophoresis, and the molecular weight was estimated as 10,000 and 15,000, respectively.
    CONCLUSIONS:
    The 50% inhibition dose of Fraction I on the first division of inseminated sea urchin eggs and on proliferation of mouse L cells was about 2.5 X 10(-5) g/ml and 5 X 10(-4) g/ml, respectively. The yield of fraction I was about 35 mg from 100 g rat liver.
    Acta Medicinae Okayama, 1965, 19(1):11-8.
    Antimitotic action of cornin as a biologically active polypeptide. I. Biochemical properties of cornin.[Reference: WebLink]
    Antimitotic action of Cornin as a biologically active polypeptide. I. Biochemical properties of Cornin.
    In vivo:
    Phytother Res. 2010 Apr;24(4):547-52.
    Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function.[Pubmed: 20041427]
    This study was conducted to investigate the efficacy of Cornin, an iridoid glycoside, in an experimental cerebral ischemia induced by middle cerebral artery occlusion (MCAO) and reperfusion (I/R), and to elucidate the potential mechanism.
    METHODS AND RESULTS:
    Adult male Sprague-Dawley rats were subjected to MCAO for 1 h, then reperfusion for 23 h. Behavioral tests were used to evaluate the damage to central nervous system. The cerebral infarct volume and histopathological damage were assessed to evaluate the brain pathophysiological changes. Spectrophotometric assay methods were used to determine the activities of superoxide dismutase (SOD) and glutathione-peroxidase (GPx). Contents of malondialdehyde (MDA), the generation of reactive oxygen species (ROS) as well as respiratory control ratio and respiratory enzymes of the brain mitochondria were also determined. The results showed that Cornin significantly decreased neurological deficit scores, and reduced cerebral infarct volume and degenerative neurons. Meanwhile, Cornin significantly increased the brain ATP content, improved mitochondrial energy metabolism, inhibited the elevation of MDA content and ROS generation, and attenuated the decrease of SOD and GPx activities in brain mitochondria.
    CONCLUSIONS:
    These findings indicate that Cornin has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property.
    Braz J Med Biol Res. 2016 Feb;49(2):e5039.
    Cardioprotection against experimental myocardial ischemic injury using cornin.[Pubmed: 26871971 ]
    Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside Cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperfusion (I/R) injury in vivo, and elucidated its potential mechanism in vitro.
    METHODS AND RESULTS:
    Effects of Cornin on cell viability, as well as expression of phospho-CREB and phospho-Akt in hypoxic H9c2 cells in vitro, and myocardial I/R injury in vivo, were investigated. Cornin attenuated hypoxia-induced cytotoxicity significantly in H9c2 cells in a concentration-dependent manner. Treatment of H9c2 cells with Cornin (10 µM) blocked the reduction of expression of phospho-CREB and phospho-Akt in a hypoxic condition. Treatment of rats with Cornin (30 mg/kg, iv) protected them from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics, and reduction of severity of myocardial damage. Cornin treatment also attenuated the reduction of expression of phospho-CREB and phospho-Akt in ischemic myocardial tissue.
    CONCLUSIONS:
    These data suggest that Cornin exerts protective effects due to an increase in expression of phospho-CREB and phospho-Akt.
    Cornin Description
    Source: The fruits of Cornus officinalis Sieb. et Zucc.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5749 mL 12.8743 mL 25.7486 mL 51.4973 mL 64.3716 mL
    5 mM 0.515 mL 2.5749 mL 5.1497 mL 10.2995 mL 12.8743 mL
    10 mM 0.2575 mL 1.2874 mL 2.5749 mL 5.1497 mL 6.4372 mL
    50 mM 0.0515 mL 0.2575 mL 0.515 mL 1.0299 mL 1.2874 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.515 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Food Chem Toxicol. 2013 Aug;58:340-6.
    Cornin induces angiogenesis through PI3K-Akt-eNOS-VEGF signaling pathway.[Pubmed: 23702325]
    In the present study, we sought to elucidate whether Cornin contributes to induce angiogenesis and its mechanisms. To this end, we examined the role of Cornin on human brain microvascular endothelial cell line (HBMEC) proliferation, invasion, and tube formation in in vitro.
    METHODS AND RESULTS:
    For study of mechanism, the phosphoinositide 3 kinase (PI3K)-Akt inhibitor LY294002, endothelial nitric oxide synthase (eNOS) inhibitor L-NAME, vascular endothelial growth factor (VEGF) antagonist sFlt-1 and VEGF receptor blocker SU-1498 were used. HMBEC proliferation was tested by MTT. Scratch adhesion test was used to assess the ability of invasion. A matrigel tube formation assay was performed to test capillary tube formation ability. PI3K-Akt-eNOS-VEGF pathway activation in HMBEC was tested by Western blot.
    CONCLUSIONS:
    Our data suggested that Cornin induces angiogenesis in vitro by increasing proliferation, invasion and tube formation. VEGF expression was increasing by Cornin and counteracted by VEGF antagonist sFlt-1, LY294002 and L-NAME in HMBEC. Tube formation was increased by Cornin and counteracted by VEGF receptor blocker-SU1498, LY294002 and L-NAME. It may be suggested that Cornin induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis.