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    Coronarin E
    Coronarin E
    CAS No. 117591-81-8 Price
    Catalog No.CFN99275Purity>=98%
    Molecular Weight284.4 Type of CompoundDiterpenoids
    FormulaC20H28OPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Coronarin E exhibits weak antimicrobial activity.
    Targets: Antifection
    Coronarin E Description
    Source: The rhizomes of Hedychium coronarium
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5162 mL 17.5809 mL 35.1617 mL 70.3235 mL 87.9044 mL
    5 mM 0.7032 mL 3.5162 mL 7.0323 mL 14.0647 mL 17.5809 mL
    10 mM 0.3516 mL 1.7581 mL 3.5162 mL 7.0323 mL 8.7904 mL
    50 mM 0.0703 mL 0.3516 mL 0.7032 mL 1.4065 mL 1.7581 mL
    100 mM 0.0352 mL 0.1758 mL 0.3516 mL 0.7032 mL 0.879 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Coronarin E References Information
    Citation [1]

    Chem Pharm Bull (Tokyo). 2008 Mar;56(3):398-403.

    Concise syntheses of coronarin A, coronarin E, austrochaparol and pacovatinin A.[Pubmed: 18310958]
    Total syntheses of (+)-coronarin A (1), (+)-Coronarin E (2), (+)-austrochaparol (3) and (+)-pacovatinin A (4) were achieved from the synthetic (+)-albicanyl acetate (6). Dess-Martin oxidation of (+)-albicanol (5) derived from the chemoenzymatic product (6) gave an aldehyde (7), which was subjected to Julia one-pot olefination using beta-furylmethyl-heteroaromatic sulfones (8 or 9 ) gave (+)-trans Coronarin E (2) and (+)-cis Coronarin E (12) with high cis-selectivity. The synthesis of (+)-coronarin A (1) from (+)-trans Coronarin E (2) was achiev-ed, while (+)-cis Coronarin E (12) was converted to the natural products (+)-(5S,9S,10S)-15,16-epoxy-8(17),13(16),14-labdatriene (13) and (+)-austrochaparol (3). By the asymmetric synthesis of (+)-3, the absolute structure of (+)-3 was determined to be 5S, 7R, 9R, 10S configurations. Homologation of (+)-albicanol (5) followed by allylic oxidation gave (7 alpha)-hydroxy nitrile (17), which was finally converted to the natural (+)-pacovatinin A (4) in 8 steps from (+)-albicanol (5).
    Citation [2]

    Asian J. Pharm. Clin. Res., 2015, 8(5):221-6.

    Chemical composition and antimicrobial activity of diterpene and essential oils of hedychium roxburghii blume rhizome[Reference: WebLink]
    Compound 1 was identified as diterpene compound, Coronarin E. Coronarin E have not exhibited MIC at 512 μg/ml, however, it showed inhibition profile against all of tested microbes. Conclusion: The essential oils and ethanolic residual-distillation extract of H. roxburghii Blume rhizome exhibited weak antimicrobial profile. Compound 1 was identified as diterpene compound, (Coronarin E), it was exhibited weak antimicrobial activity, but showed inhibition profile against all of the tested microbes.