|Description:||1. Coronarin E exhibits weak antimicrobial activity.|
|Source:||The rhizomes of Hedychium coronarium|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.5162 mL||17.5809 mL||35.1617 mL||70.3235 mL||87.9044 mL|
|5 mM||0.7032 mL||3.5162 mL||7.0323 mL||14.0647 mL||17.5809 mL|
|10 mM||0.3516 mL||1.7581 mL||3.5162 mL||7.0323 mL||8.7904 mL|
|50 mM||0.0703 mL||0.3516 mL||0.7032 mL||1.4065 mL||1.7581 mL|
|100 mM||0.0352 mL||0.1758 mL||0.3516 mL||0.7032 mL||0.879 mL|
Chem Pharm Bull (Tokyo). 2008 Mar;56(3):398-403.
|Concise syntheses of coronarin A, coronarin E, austrochaparol and pacovatinin A.[Pubmed: 18310958]|
|Total syntheses of (+)-coronarin A (1), (+)-Coronarin E (2), (+)-austrochaparol (3) and (+)-pacovatinin A (4) were achieved from the synthetic (+)-albicanyl acetate (6). Dess-Martin oxidation of (+)-albicanol (5) derived from the chemoenzymatic product (6) gave an aldehyde (7), which was subjected to Julia one-pot olefination using beta-furylmethyl-heteroaromatic sulfones (8 or 9 ) gave (+)-trans Coronarin E (2) and (+)-cis Coronarin E (12) with high cis-selectivity. The synthesis of (+)-coronarin A (1) from (+)-trans Coronarin E (2) was achiev-ed, while (+)-cis Coronarin E (12) was converted to the natural products (+)-(5S,9S,10S)-15,16-epoxy-8(17),13(16),14-labdatriene (13) and (+)-austrochaparol (3). By the asymmetric synthesis of (+)-3, the absolute structure of (+)-3 was determined to be 5S, 7R, 9R, 10S configurations. Homologation of (+)-albicanol (5) followed by allylic oxidation gave (7 alpha)-hydroxy nitrile (17), which was finally converted to the natural (+)-pacovatinin A (4) in 8 steps from (+)-albicanol (5).|
Asian J. Pharm. Clin. Res., 2015, 8(5):221-6.
|Chemical composition and antimicrobial activity of diterpene and essential oils of hedychium roxburghii blume rhizome[Reference: WebLink]|
|Compound 1 was identified as diterpene compound, Coronarin E. Coronarin E have not exhibited MIC at 512 μg/ml, however, it showed inhibition profile against all of tested microbes. Conclusion: The essential oils and ethanolic residual-distillation extract of H. roxburghii Blume rhizome exhibited weak antimicrobial profile. Compound 1 was identified as diterpene compound, (Coronarin E), it was exhibited weak antimicrobial activity, but showed inhibition profile against all of the tested microbes.|