ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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More articles cited ChemFaces products.
Chem Biol Interact. 2016 Dec 25Biochem Pharmacol. 2017 Apr 15;Integr Med Res.2017 Dec;Phytomedicine2015 March 20.Microchemical JournalMarch 2018;
J Ethnopharmacol. 2017 Jan 20;Korean Society of Pharm. Sci.2017;Biochem Biophys Res Commun.2017 Jan 22;BMC Complement Altern Med.2014 Jul 14;14:242.Arch Toxicol. 2017 Mar 20.
Evid Based Complement Alternat Med. 2016 Jun 13.Exp Parasitol.2017 Dec;Org Biomol Chem. 2017 Jul 25.Br J Pharmacol.2016 Jan;173(2):396-410.
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (U... (Brazil)University of Amsterdam (Netherlands)Weizmann Institute of Science (Israel)University of the Basque Country (Spain)
Universit?t Basel (Switzerland)Cancer Research Initatives Found... (Malaysia)Washington State University (USA)Institute of Pathophysiology Med... (Austria)
Uniwersytet Medyczny w ?odzi (Poland)Florida A&M University (USA)University of Pretoria (South Africa)
||Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase(AChE) with the IC50 value of 30.6 microM, which exhibits the potent anti-inflammatory and/or immunosuppressive activity, the potent inhibitory activity of corynoline for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases.
|Bioorg Med Chem. 2005 Mar 1;13(5):1867-72. |
|Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study.[Pubmed: 15698804 ]|
|Corynoline (1), a hexahydrobenzo[c]phenanthridine-type alkaloid, exhibited the concentration-dependent inhibition for the adhesion of human polymorphonuclear leukocyte and eosinophil to human umbilical vein cultured endothelial cell in the concentration range of showing no significant cytotoxicity for the cell: IC(50) value=72.4 microM for (d)-1 and 156.7 microM for (l)-1.
This shows the potent anti-inflammatory and/or immunosuppressive activity of 1.
METHODS AND RESULTS:
To elucidate possible structure-activity relationship, the conformational/structural feature of (d)-1 was investigated by X-ray crystal structure analysis and molecular orbital energy calculations, and the docking study was performed for its interaction with the D1-domain of ICAM-1 (intracellular adhesion molecule-1). A plausible model was proposed, in which all polar atoms of (d)-1 are linked by hydrogen bonds or electrostatic interactions with the functional residues of ICAM-1, that have been supposed to be necessary for the binding with LFA-1 (leukocyte function-associated antigen-1).
This suggests the potent inhibitory activity of 1 for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases.
||The tubers of Corydalis ambigua
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Arch Pharm Res. 2002 Dec;25(6):817-9. |
|Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase.[Pubmed: 12510831]|
METHODS AND RESULTS:
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE.
Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
|Tetrahedron Letters Volume 27, Issue 19, 1986, Pages 2103–2106 |
|Synthesis of a hypothetical intermediate in the biosynthesis of the 13-methylbenzophenanthridine alkaloids corynoline and 14-epicorynoline and the B-secoprotoberberine alkaloid corydalic acid methyl ester[Reference: WebLink]|
|A novel carbinolammonium chloride has been synthesized as a possible intermediate in the biosynthetic conversion of the 13-methylprotoberberine alkaloid (+)-tetrahydrocorysamine to the benzophenanthridine alkaloids (+)-Corynoline, (+)-14-epicorynoline, and the B-secoprotoberberine alkaloid (+)-corydalic acid methyl ester.|