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More articles cited ChemFaces products.
J Pharm Biomed Anal. 2017 Jun 5;Evidence-Based Complementary & Alternative Med.2017J Ethnopharmacol. 2016 Jul 12.Arch Biochem Biophys. 2018 Jan 15;Inflammation.2015 Feb;38(1):445-55.
J Agric Food Chem. 2017 Apr 5Aquaculture1 Dec. 2017Mol. & Cell. ToxicologySep. 2017;Journal of Functional FoodsFeb. 2018;Plant J. 2017 May;
Phytomedicine2015 August 14Srinagarind Medical JournalNo 1 (2017) Phytomedicine.2018 Jan 1;Lab On a Chip21 Feb 2018;
Our products had been exported to the following research institutions and universities, And still growing.
National Research Council of Can... (Canada)Universidade Católica Portuguesa (Portugal)Max Rubner-Institut (MRI) (Germany)Worcester Polytechnic Institute (USA)
Celltrion Chemical Research Inst... (Korea)Stanford University (USA)Warszawski Uniwersytet Medyczny (Poland)Heidelberg University (Germany)
Wroclaw Medical University (Poland)University of Helsinki (Finland)University of Hertfordshire (United Kingdom)
||Cyanidin Chloride, the main phenolic antioxidant in the grape (Vitis vinifera), in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.
It has a dual effect on RANKL-induced osteoclastogenesis, exhibits therapeutic potential in prevention of osteoclasts related bone disorders.|
||HbA1c glycation | LXR-β | NFATc1 | c-Fos | Mitf|
|Biochem Pharmacol. 1996 Oct 11;52(7):1033-9. |
|Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L.[Pubmed: 8831722]|
METHODS AND RESULTS:
No attention has been paid to anthocyanin pigments from the viewpoint of inhibitors of lipid peroxidation and scavengers of active oxygen radicals; therefore, we investigated the antioxidative, radical scavenging, and inhibitory effects on lipid peroxidation by UV light irradiation of three anthocyanin pigments, pelargonidin 3-O-beta-D-glucoside (P3G), cyanidin 3-O-beta-D-glucoside (C3G), and delphinidin 3-O-beta-D-glucoside (D3G), isolated from the Phaseolus vulgaris L. seed coat, and their aglycons, pelargonidin chloride (Pel), Cyanidin Chloride (Cy), and delphinidin chloride (Del).
All pigments had strong antioxidative activity in a liposomal system and reduced the formation of malondialdehyde by UVB irradiation. On the other hand, the extent of antioxidative activity in a rat liver microsomal system and the scavenging effect of hydroxyl radicals (-OH) and superoxide anion radicals (O2-) were influenced by their own structures.
|Planta Med. 2013 Nov;79(17):1599-604. |
|Treatment of diabetes in the mouse model by delphinidin and cyanidin hydrochloride in free and liposomal forms.[Pubmed: 24108435]|
|Cyanidin Chloride and delphinidin are the main phenolic antioxidants in the grape (Vitis vinifera). The aim of this study was to investigate the in vitro and in vivo inhibitory effects of delphinidin and Cyanidin Chloride in the free and liposomal forms on the albumin glycation reaction.
METHODS AND RESULTS:
Delphinidin and Cyanidin Chlorides were encapsulated in the liposomes using an extrusion method. The rate of albumin glycation was evaluated using the ELISA method. Finally, in vivo anti-glycation of delphinidin and Cyanidin Chloride in the free and liposomal forms in diabetic mice was investigated. The encapsulation efficacies of delphinidin and Cyanidin Chloride in the liposomes were 89.05 % ± 0.18 and 85.00 % ± 0.15, respectively. In vitro treatment with 100 mg/mL delphinidin and Cyanidin Chloride in free forms could reduce the rate of albumin glycation to 30.50 ± 3.46 and 46.00 ± 2.50 %, respectively. Under identical conditions, the delphinidin and Cyanidin Chloride-loaded liposomes could reduce the rate of albumin glycation to 8.50 ± 2.10 and 14.60 ± 3.60 %, respectively. In vivo testing showed that anti-glycation activity of delphinidin and cyanidin in loaded forms was higher than in free forms. The daily administration of 100 mg/kg delphinidin chloride-loaded liposomes to diabetic mice at eight weeks could decrease the rate of albumin and HbA1c glycation to 46.35 ± 1.20 and 3.60 ± 0.25 %, respectively. Moreover, under identical conditions, the loaded liposomes with Cyanidin Chloride could decrease the rate of albumin and HbA1c glycation to 55.56 ± 1.32 and 4.95 ± 0.20 %, respectively.
The findings showed that delphinidin and Cyanidin Chloride, in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.
Cyanidin Chloride Description
||The peels of Glycinemax (L.) merr
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Cell Physiol. 2014 Dec 24. |
|Dual Effect of Cyanidin on RANKL-Induced Differentiation and Fusion of Osteoclasts.[Pubmed: 25545964]|
|Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoclasts are multinucleated cells derived from hematopoietic stem cells (HSCs) or monocyte/macrophage progenitor cells and formed by osteoclasts precursors (OCPs) fusion. Cyanidin Chloride is an anthocyanin widely distributed in food diet with novel antioxidant activity. However, the effect of Cyanidin Chloride on osteoclasts is still unknown.
METHODS AND RESULTS:
We investigated the effect of Cyanidin Chloride on RANKL-induced osteoclasts differentiation and cell fusion. The results showed that Cyanidin Chloride had a dual effect on RANKL-induced osteoclastogenesis. Lower dosage of cyanidin (< 1μg/ml) has a promoting effect on osteoclastogenesis while higher dosage of Cyanidin Chloride (> 10μg/ml) has an inhibitory effect. Fusogenic genes like CD9, ATP6v0d2, DC-STAMP, OC-STAMP and osteoclasts related genes like NFATc1, mitf and c-fos were all regulated by Cyanidin Chloride consistent to its dual effect. Further exploration showed that low concentration of Cyanidin Chloride could increase osteoclasts fusion whereas higher dosage of cyanidin lead to the increase of LXR-β expression and activation which is suppressive to osteoclasts differentiaton.
All these results showed that Cyanidin Chloride exhibits therapeutic potential in prevention of osteoclasts related bone disorders.