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    Daphniyunnine A
    Information
    CAS No. 881388-87-0 Price
    Catalog No.CFN97447Purity>=98%
    Molecular Weight369.5 Type of CompoundAlkaloids
    FormulaC23H31NO3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Description: Daphniyunnine A is a natural product from Daphniphyllum macropodum Miq.
    Daphniyunnine A Description
    Source: The leaves and stems of Daphniphyllum macropodum Miq.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7064 mL 13.5318 mL 27.0636 mL 54.1272 mL 67.659 mL
    5 mM 0.5413 mL 2.7064 mL 5.4127 mL 10.8254 mL 13.5318 mL
    10 mM 0.2706 mL 1.3532 mL 2.7064 mL 5.4127 mL 6.7659 mL
    50 mM 0.0541 mL 0.2706 mL 0.5413 mL 1.0825 mL 1.3532 mL
    100 mM 0.0271 mL 0.1353 mL 0.2706 mL 0.5413 mL 0.6766 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2006 Apr;69(4):553-7.
    Daphniyunnines A-E, alkaloids from Daphniphyllum yunnanense.[Pubmed: 16643024 ]

    METHODS AND RESULTS:
    The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of five new alkaloids, Daphniyunnine A, daphniyunnine B, daphniyunnine C, daphniyunnine D, daphniyunnine E (1-5). Daphniyunnines B-E (2-5) are four unusual C-22 nor-Daphniphyllum alkaloids.
    CONCLUSIONS:
    The structures of these alkaloids were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X-ray diffraction analysis was used to confirm the structure of 1. Daphniyunnine D (4) showed cytotoxicity against two tumor cell lines, P-388 and A-549, with IC(50) values of 3.0 and 0.6 microM, respectively.