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    CAS No. 6659-45-6 Price
    Catalog No.CFN90585Purity>=98%
    Molecular Weight396.43Type of CompoundMiscellaneous
    FormulaC23H24O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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  • Biological Activity
    Description: Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.
    Targets: p21 | p53 | Akt | ERK | JNK | p38MAPK
    In vitro:
    J Biochem Mol Toxicol. 2014 May;28(5):232-8.
    Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle.[Pubmed: 24615755]
    Dihydrorotenone (DHR) is a natural pesticide used for farming including organic produces. We recently found that Dihydrorotenone induces human plasma cell apoptosis by provoking endoplasmic reticulum stress.
    In the present study, we found that Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression.
    Therefore, these results collectively demonstrated that Dihydrorotenone disrupts the cell cycle progress, which suggests that Dihydrorotenone is toxic to human plasma cells. Caution is thus suggested when handling with this agent.
    Dihydrorotenone Description
    Source: The herbs of Derris trifoliata Lour.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5225 mL 12.6126 mL 25.2251 mL 50.4503 mL 63.0628 mL
    5 mM 0.5045 mL 2.5225 mL 5.045 mL 10.0901 mL 12.6126 mL
    10 mM 0.2523 mL 1.2613 mL 2.5225 mL 5.045 mL 6.3063 mL
    50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.009 mL 1.2613 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5045 mL 0.6306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kinase Assay:
    PLoS One. 2013 Jul 26;8(7):e69911.
    The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.[Pubmed: 23922854]
    Dihydrorotenone (DHR) is a natural pesticide widely used in farming industry, such as organic produces. Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome, however, it is not known whether Dihydrorotenone is toxic to other systems.
    In the present study, we evaluated the cytotoxicity of Dihydrorotenone on human plasma cells. As predicted, Dihydrorotenone impaired mitochondrial function by decreasing mitochondrial membrane potential in plasma cells. Because mito-dysfunction leads to unfolded protein response (UPR) and endoplasmic reticulum (ER) stress, we examined the signature proteins in ER stress, including GRP78, ATF4, and CHOP. After Dihydrorotenone treatment, these proteins were significantly upregulated. It is reported that activation of the mitogen-activated protein kinases p38 and JNK are involved in endoplasmic reticulum stress. However, in the subsequent study, Dihydrorotenone was found to activate p38 but not the JNK signaling. When pre-treated with p38 inhibitor SB203580, activation of p38 and cell apoptosis induced by Dihydrorotenone was partially blocked.
    Thus, we found that Dihydrorotenoneinduced human plasma cell death by activating the p38 but not the JNK signaling pathway. Because plasma cells are very important in the immune system, this study provided a new insight in the safety evaluation of Dihydrorotenone application.