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    Methylgomisin O
    Methylgomisin O
    CAS No. N/A Price $318 / 5mg
    Catalog No.CFN95236Purity>=98%
    Molecular Weight430.5Type of CompoundLignans
    FormulaC24H30O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $318 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Methylgomisin O has anti- inflammatory activity, it -induced attenuation of inflammatory cytokine production upon exposure to LPS was at least partially mediated by the suppression of NF-κB and MAPK pathway. Methylgomisin O exhibits strong cytotoxic effects on HL-60. It exhibits considerable inhibitory activity against tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).
    Targets: NF-κB | MAPK | TNF-α | IL Recepter
    In vitro:
    Chinese journal of veterinary science, 2011, 31(9):1309-1308.
    Anti-inflammatory effect and mechanism of methylgomisin O.[Reference: WebLink]
    Methylgomisin O was a new dibenzocyclooctadiene lignan isolated from the fruits of Schisandra sphenanthera.
    In this paper,we investigated in vitro[LPS-induced murine RAW264.7 macrophages],the effect of Methylgomisin O on the generation of cytokines involved in the inflammatory process,such as TNF-α,IL-1β,IL-6 and IL-10.We further investigated the effect of Methylgomisin O on the LPS-induced activation of NF-κB and MAPK pathway.The result was that 0.5,2.5 and 12.5 mg/L of Methylgomisin O significantly decreased the production of TNF-α and IL-6,but didn't have significant effect on IL-1β and IL-10.Signal transduction studies showed that Methylgomisin O significantly inhibited p65-NF-κB and MAPK in a dose-dependence manner.
    Accordingly,we concluded that Methylgomisin O-induced attenuation of inflammatory cytokine production upon exposure to LPS was at least partially mediated by the suppression of NF-κB and MAPK pathway.
    Korean journal of food science & technology, 2014, 46(6):665-670.
    The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis.[Reference: WebLink]
    We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract.
    Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) chamigrenal, (7) schisanlactone D, (8) Methylgomisin O, (9) angeloylgomisin O, (10) (-)-gomisin L2, (11) schisandronic acid, (12) (-)-gomisin L1, (13) (+)-gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines.
    Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 μM, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 μM). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 μM).
    Zeitschrift Für Naturforschung B, 2010, 65(2):1-8.
    New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Proinflammatory Cytokine Inhibitory Activities.[Reference: WebLink]

    Investigation of the fruits of Schisandra sphenanthera led to the isolation of two new dibenzocyclooctadiene lignans, Methylgomisin O (1) and chloromethyl schisantherin B (2), together with twelve known lignans (3-14). Their structures were elucidated by using extensive spectroscopic techniques including 1D and 2D NMR spectra. Compound 2 was identified as a cyclooctadiene moiety substituted with a chloromethyl group, which is rarely found in natural products, especially in terrestrial higher plants.
    Among these isolates, compounds 1 and 7 exhibited considerable inhibitory activity against tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, and did not display any cellular toxicity against RAW264.7 cells.
    Methylgomisin O Description
    Source: The fruits of Schisandra viridis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3229 mL 11.6144 mL 23.2288 mL 46.4576 mL 58.072 mL
    5 mM 0.4646 mL 2.3229 mL 4.6458 mL 9.2915 mL 11.6144 mL
    10 mM 0.2323 mL 1.1614 mL 2.3229 mL 4.6458 mL 5.8072 mL
    50 mM 0.0465 mL 0.2323 mL 0.4646 mL 0.9292 mL 1.1614 mL
    100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.4646 mL 0.5807 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.