Dihydroxyaflavinine | CAS:76410-56-5 | Manufacturer ChemFaces

Dihydroxyaflavinine

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Description:

Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea).

Targets:

GABA Receptor

In vitro:

Sheng Li Xue Bao. 1991 Jun;43(3):227-35.

Fungal toxin dihydroxyaflavinine inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.[Pubmed: 1664974]

Dihydroxyaflavinine is an indole-derived metabolite of Aspergillus flavus.
METHODS AND RESULTS:
Its action on GABA-induced response was quantitatively studied on the GABAA receptor expressed in Xenopus oocytes after injection of chick brain mRNA under voltage-clamp conditions. Dihydroxyaflavinine inhibits GABA-induced current non-competitively with KI = 12 mumol/L. This blockage is rapidly reversible. In comparison, the inhibitory effect of penicillin on GABAA receptor is enhanced by increasing GABA concentration. Ro 15-1788 (a benzodiazepine ligand with KD = 0.6--2 nmol/L) of concentration as high as 1 mumol/L, does not mask the action of 10 mumol/L Dihydroxyaflavinine, indicating that Dihydroxyaflavinine acts on a site different from benzodiazepines.
CONCLUSIONS:
Dihydroxyaflavinine appears to expedite desensitization of the receptor, which is similar to the action of picrotoxin and in contrast with that of penicillin and bicuculline.

J Antibiot (Tokyo). 1988 Dec;41(12):1868-72.

Toxicity of selected tremorgenic mycotoxins and related compounds to Spodoptera frugiperda and Heliothis zea.[Pubmed: 3209479]

METHODS AND RESULTS:
A series of tremorgenic mycotoxins and related compounds were tested for oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea) by incorporation of materials into artificial diets and examining mortality and weights after 7 days. Significant mortality to both insect species was caused with Dihydroxyaflavinine and roseotoxin B, while significant mortality to H. zea was also caused by penitrem A at 25 ppm. After 7 days, weighs of larvae treated with 25 ppm penitrem A, roseotoxin B, and verruculogen were less than 50% of controls for both insect species. Weights of H. zea larvae treated with 25 ppb of penitrem A were less than 50% those of control larvae. Relative toxicities of the tremorgens and related compounds to insects compared to vertebrates are discussed.

Dihydroxyaflavinine Description

Source:	The metabolites of Aspergillus flavus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dihydroxyaflavinine
Price:
CAS No.:	76410-56-5
Catalog No.:	CFN89093
Molecular Formula:	C₂₈H₃₉NO₃
Molecular Weight:	437.62 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The metabolites of Aspergillus flavus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library GABA(A) receptor blockers Compound Library Diterpenoids Compound Library GABA Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2851 mL	11.4254 mL	22.8509 mL	45.7018 mL	57.1272 mL
5 mM	0.457 mL	2.2851 mL	4.5702 mL	9.1404 mL	11.4254 mL
10 mM	0.2285 mL	1.1425 mL	2.2851 mL	4.5702 mL	5.7127 mL
50 mM	0.0457 mL	0.2285 mL	0.457 mL	0.914 mL	1.1425 mL
100 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.457 mL	0.5713 mL

CFN90476	Anisic aldehyde	123-11-5	136.14	C₈H₈O₂
CFN00506	11-(Methylsulfinyl)undecylglucosinolate	N/A	573.8	C₁₉H₃₆KNO₁₀S₃
CFN97280	Padmatin	80453-44-7	318.3	C₁₆H₁₄O₇
CFN96296	1-Methyl-2-undecylquinolin-4(1H)-one	59443-02-6	313.5	C₂₁H₃₁NO