Dunnianol | CAS:139726-29-7 | Manufacturer ChemFaces

Dunnianol

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.

Targets:

NF-kB | NOS | ROS

In vitro:

Planta Med.,2014, 80(10):807-807.

Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink]

Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis.
METHODS AND RESULTS:
Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii. Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which Dunnianol, macranthol and isoDunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%.
CONCLUSIONS:
These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.

Dunnianol Description

Source:	The fruits of Illicium fargesii.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dunnianol
Price:
CAS No.:	139726-29-7
Catalog No.:	CFN99448
Molecular Formula:	C₂₇H₂₆O₃
Molecular Weight:	398.5 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The fruits of Illicium fargesii.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Neuroprotection Compound Library Anticholinesterase Compound Library Lignans Compound Library ROS Inhibitor Library NOS Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5094 mL	12.5471 mL	25.0941 mL	50.1882 mL	62.7353 mL
5 mM	0.5019 mL	2.5094 mL	5.0188 mL	10.0376 mL	12.5471 mL
10 mM	0.2509 mL	1.2547 mL	2.5094 mL	5.0188 mL	6.2735 mL
50 mM	0.0502 mL	0.2509 mL	0.5019 mL	1.0038 mL	1.2547 mL
100 mM	0.0251 mL	0.1255 mL	0.2509 mL	0.5019 mL	0.6274 mL

CFN91498	4'-O-Methylhonokiol	68592-15-4	280.4	C₁₉H₂₀O₂
CFN91499	2-O-Methylhonokiol	68592-19-8	280.4	C₁₉H₂₀O₂
CFN91500	Di-O-methylhonokiol	68592-18-7	294.4	C₂₀H₂₂O₂
CFN99449	Isodunnianol	139726-30-0	398.5	C₂₇H₂₆O₃
CFN99448	Dunnianol	139726-29-7	398.5	C₂₇H₂₆O₃
CFN99661	Simonsinol	155709-40-3	398.5	C₂₇H₂₆O₃
CFN96079	Magnolianin	147663-91-0	827.0	C₅₄H₅₀O₈
CFN96188	Magnolignan A	93673-81-5	300.4	C₁₈H₂₀O₄
CFN96189	Magnolignan C	93697-42-8	300.4	C₁₈H₂₀O₄
CFN95076	(1S,2S)-threo-Honokitriol	1099687-80-5	316.4	C₁₈H₂₀O₅