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    Dunnianol
    Information
    CAS No. 139726-29-7 Price
    Catalog No.CFN99448Purity>=98%
    Molecular Weight398.5 Type of CompoundLignans
    FormulaC27H26O3Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Dunnianol Description
    Source: The fruits of Illicium fargesii.
    Biological Activity or Inhibitors: 1. Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
    5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
    10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
    50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
    100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Dunnianol References Information
    Citation [1]

    Synlett (Impact Factor: 2.46). 03/2010; 2010(04):633-635.

    A Concise Synthesis of Dunnianol[Reference: WebLink]
    A short total synthesis of the neosesquilignan Dunnianol which features a double Suzuki cross-coupling as a key step is described.
    Citation [2]

    Planta Med.,2014, 80(10):807-807.

    Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink]
    Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis. Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii. Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which Dunnianol, macranthol and isoDunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%. These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.