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    Echinacoside
    Information
    CAS No. 82854-37-3 Price $90 / 20mg
    Catalog No.CFN98105Purity>=98%
    Molecular Weight786.72Type of CompoundPhenylpropanoids
    FormulaC35H46O20Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Echinacoside Description
    Source: The rhizomes of Cistanche tubulosa (Schenk) Wight
    Biological Activity or Inhibitors: 1. Echinacoside can provide a pronounced protection against GalN/LPS-induced acute liver injury in mice.
    2. Echinacoside could improve the hematopoietic function of bone marrow in 5-FU-induced myelosuppression mice.
    3. Echinacoside could increase viability of rat pheochromocytoma PC12 cells injured by Aβ and suppress the increase in intracellular reactive oxygen species (ROS) triggered by Aβ.
    4. Echinacoside inhibits against 6-OHDA-induced neurotoxicity, the mechanism may be involve in attenuating mitochondrial dysfunction and inflammatory responses by reducing ROS production.
    5. Transient treatment with Echinacoside inhibits cytochrome c release and caspase-3 activation caused by ensuing rotenone exposure via activating Trk-extracellular signal-regulated kinase (ERK) pathway in neuronal cells.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2711 mL 6.3555 mL 12.711 mL 25.422 mL 31.7775 mL
    5 mM 0.2542 mL 1.2711 mL 2.5422 mL 5.0844 mL 6.3555 mL
    10 mM 0.1271 mL 0.6356 mL 1.2711 mL 2.5422 mL 3.1778 mL
    50 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.5084 mL 0.6356 mL
    100 mM 0.0127 mL 0.0636 mL 0.1271 mL 0.2542 mL 0.3178 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Echinacoside References Information
    Citation [1]

    Scand J Gastroenterol. 2014 Aug;49(8):993-1000.

    Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation.[Pubmed: 24797709]
    OBJECTIVE: This study aimed to investigate the protective effects of Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, a Chinese herbal medicine, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced acute liver injury in mice. Pretreatment with Echinacoside remarkably improved the survival rate of GalN/LPS-treated mice and attenuated acute hepatotoxicity, as demonstrated by decreased ALT levels and improved histological signs. Echinacoside shows both anti-apoptotic and anti-inflammatory properties, characterized by a substantial inhibition of hepatocyte apoptosis and a significant reduction in the inflammatory markers, including myeloperoxidase, extracellular nucleosomes, high-mobility group box 1, and inflammatory cytokines in the plasma of mice, which may be important mechanisms related to its protective effect. CONCLUSION: Our results suggest that Echinacoside can provide a pronounced protection against GalN/LPS-induced acute liver injury in mice, which may complement the available strategies for management of acute liver damage in clinical settings.
    Citation [2]

    Evid Based Complement Alternat Med. 2015;2015:189239.

    Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production.[Pubmed: 25788961]
    Echinacoside (ECH) is a phenylethanoid glycoside isolated from the stems of Cistanche salsa, showing a variety of neuroprotective effects in previous studies. The present study was to investigate its effect against 6-OHDA-induced neurotoxicity and possible mechanisms in PC12 cells. The results showed that 6-OHDA reduced cell viability, decreased oxidation-reduction activity, decreased mitochondrial membrane potential, and induced mitochondria-mediated apoptosis compared with untreated PC12 cells. However, Echinacoside treatment significantly attenuated these changes induced by 6-OHDA. In addition, Echinacoside also could significantly alleviate the inflammatory responses induced by 6-OHDA. Further research showed that Echinacoside could reduce 6-OHDA-induced ROS production in PC12 cells. These results suggest that the underlying mechanism of Echinacoside against 6-OHDA-induced neurotoxicity may be involve in attenuating mitochondrial dysfunction and inflammatory responses by reducing ROS production.
    Citation [3]

    Life Sci. 2015 Feb 15;123:86-92.

    Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice.[Pubmed: 25623854]
    AIMS: We aimed to investigate the effects of Echinacoside (ECH) on hematopoietic function in 5-FU-induced bone marrow depression mice. MAIN METHODS: In vitro, after stimulation with Echinacoside, the proliferation ability of bone marrow (BM) cells and bone marrow stromal cells (BMSCs) derived from myelosuppression mice were assessed by CCK8 assay and morphology, respectively. In vivo, 5-FU-induced myelosuppression or control mice were intragastrically administrated with either Echinacoside at 15 mg/kg or the equal volume of normal saline daily for 12 days before BM cells were isolated for colony-forming cell assay. Meanwhile, BMSCs were cultured for 4 weeks before cells were observed for growth pattern, cell culture supernatants were collected for GM-CSF secretion by ELISA, and RNA of the cells were extracted for EPO and GM-CSF RT-PCR. BM cells or BMSCs stimulated with Echinacoside for 24 h or 48 h were collected for protein extraction and Western blotting. KEY FINDINGS: Echinacoside stimulated the growth of BM cells but not BMSCs derived from 5-FU treated mice. The intragastric administration of Echinacoside in 5-FU treated mice could increase the number of total hematopoietic progenitor cells and GM progenitor cells to healthy control mice level, but not BFU progenitor cells. BMSCs from Echinacoside treated myelosuppression mice grew more vigorously and expressed more GM-CSF, but not EPO. Echinacoside activated the PI3K signaling pathway in 5-FU suppressed BM cells. SIGNIFICANCE: Echinacoside could improve the hematopoietic function of bone marrow in 5-FU-induced myelosuppression mice. Echinacoside can be considered as an alternative effective therapy for patients during chemotherapy or HSC transplantation.
    Citation [4]

    J Neurochem. 2013 Feb;124(4):571-80.

    Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone.[Pubmed: 23189969]
    We reported that Echinacoside, a small natural compound, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside is the major active component of Cistanches Herba, a widely used Chinese herb with neuroprotective effects. We showed in this study that transient exposure to Echinacoside is sufficient to protect neuronal cells and non-neuronal cells over-expressed with TrkA or TrkB against rotenone injury. Additional investigations on the mechanisms underlying suggested that transient treatment with Echinacoside inhibits cytochrome c release and caspase-3 activation caused by ensuing rotenone exposure via activating Trk-extracellular signal-regulated kinase (ERK) pathway in neuronal cells. As Echinacoside is able to cross the blood-brain barrier freely, it may have a promising potential in neurodegenerative diseases treatment.
    Citation [5]

    Int J Biol Macromol. 2015 Jan;72:243-53.

    Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity.[Pubmed: 25193102]
    We investigated the protection provided by Echinacoside against neurotoxicity induced by β-amyloid protein (Aβ). Through spectroscopic analyses, electron microscopy, cell viability assay, and hemolysis assay, we found that Echinacoside dose dependently inhibited HEWL aggregation, and this inhibition occurred in different fiber-forming stages. Echinacoside could also scavenge the DPPH and OH free radicals in a concentration-dependent manner. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 2',7'-dichlorodihydrofluoresceindiacetate (DCFH-DA) fluorescent measurement results indicated that Echinacoside could increase viability of rat pheochromocytoma PC12 cells injured by Aβ and suppress the increase in intracellular reactive oxygen species (ROS) triggered by Aβ. The present study findings facilitate a better understanding of the interaction between Echinacoside and amyloid-forming proteins and also shed light on the protection of Echinacoside against amyloid fibril-induced neuronal cell death.