• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Isoliquiritin apioside
    Isoliquiritin apioside
    Information
    CAS No. 120926-46-7 Price $338 / 10mg
    Catalog No.CFN90800Purity>=98%
    Molecular Weight550.5Type of CompoundFlavonoids
    FormulaC26H30O13Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Sri Sai Aditya Institute of Phar... (India)
  • Heidelberg University (Germany)
  • Weizmann Institute of Science (Israel)
  • Mendel University in Brno (Czech Republic)
  • Kyung Hee University (Korea)
  • Universiti Sains Malaysia (Malaysia)
  • Universidad de Buenos Aires (Argentina)
  • Hamdard University (India)
  • University of Fribourg (Switzerland)
  • Institute of Bioorganic Chemistr... (Poland)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • Package
    Featured Products
    3,5-Di-O-caffeoylquinic methyl ester

    Catalog No: CFN90857
    CAS No: 159934-13-1
    Price: $388/5mg
    Isoacteoside

    Catalog No: CFN97049
    CAS No: 61303-13-7
    Price: $178/20mg
    Platycoside M1

    Catalog No: CFN92267
    CAS No: 917482-67-8
    Price: $468/5mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $358/10mg
    Baicalin

    Catalog No: CFN99111
    CAS No: 21967-41-9
    Price: $50/20mg
    Isoliquiritin apioside Description
    Source: The roots of Glycyrrhiza uralensis
    Biological Activity or Inhibitors: 1. Isoliquiritin apioside with marked potential to combat oxidative stress-induced genotoxicity.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8165 mL 9.0827 mL 18.1653 mL 36.3306 mL 45.4133 mL
    5 mM 0.3633 mL 1.8165 mL 3.6331 mL 7.2661 mL 9.0827 mL
    10 mM 0.1817 mL 0.9083 mL 1.8165 mL 3.6331 mL 4.5413 mL
    50 mM 0.0363 mL 0.1817 mL 0.3633 mL 0.7266 mL 0.9083 mL
    100 mM 0.0182 mL 0.0908 mL 0.1817 mL 0.3633 mL 0.4541 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isoliquiritin apioside References Information
    Citation [1]

    Eur J Pharmacol. 2003 May 23;469(1-3):159-63.

    Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang).[Pubmed: 12782198]
    We attempted to elucidate the antitussive principles of Glycyrrhizae radix, a main component of Bakumondo-to (Mai-men-dong-tang). Although the 50% methanol-eluted fraction (100 mg/kg, p.o.) caused a more than 60% reduction in the number of capsaicin-induced coughs, neither the water-eluted nor 100% ethanol-eluted fractions of water extract of G. radix had antitussive effects. The water extract of G. radix contained high levels of liquiritin, liquiritin apioside, isoliquiritin, Isoliquiritin apioside and glycyrrhizin. On the other hand, the 50% methanol-eluted fraction contained mainly liquiritin and liquiritin apioside, but not the other compounds. Liquiritin apioside (3-30 mg/kg, p.o.), but not liquiritin, isoliquiritin, Isoliquiritin apioside or glycyrrhizin, dose-dependently inhibited the number of coughs. Methysergide, a serotonin receptor antagonist, antagonized the antitussive effect of liquiritin apioside. However, the antitussive effect of liquiritin apioside was not antagonized by naloxone. Pretreatment with glibenclamide (3 mg/kg, i.p.), an ATP-sensitive potassium channel blocker, also significantly reduced the antinociceptive effect of liquiritin apioside. These results suggest that G. radix contains a potent antitussive compound, liquilitin apioside, whose antitussive effect may depend on both peripheral and central mechanisms.
    Citation [2]

    Toxicol In Vitro. 2009 Jun;23(4):680-6.

    Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.[Pubmed: 19490840]
    Prevention of manifestation of events characteristic of carcinogenesis is being emphasized a rational strategy to combat cancer. Reactive oxygen species (ROS) play an important role in tumor initiation through oxidative damage of DNA. In search for lead molecules in cancer chemoprevention from natural products, a fraction 'Rlicca' isolated from Glycyrrhiza glabra was studied for modulatory effect against hydrogen peroxide and 4-nitroquinoline-N-oxide induced genotoxicity in Escherichiacoli PQ37 using SOS chromotest and in human peripheral blood lymphocytes using the Comet assay. The fraction 'Rlicca' at a concentration of 191 microM decreased the SOS inducing potency (SOSIP) of hydrogen peroxide (1.0mM) and NQO (20 microg/ml) by 83.72% and 68.77%, respectively. In the human blood lymphocytes, 'Rlicca' reduced the tail moment induced by hydrogen peroxide (25 microM) and NQO (5 microg/ml) by 88.04% and 76.64%, respectively, using the Comet assay. The spectroscopic data of 'Rlicca' fraction revealed it to be Isoliquiritin apioside, a chalcone oligoglycoside. This is the first report of Isoliquiritin apioside with marked potential to combat oxidative stress-induced genotoxicity.