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    Epimedin C
    Information
    CAS No. 110642-44-9 Price $100 / 20mg
    Catalog No.CFN99941Purity>=98%
    Molecular Weight822.80Type of CompoundFlavonoids
    FormulaC39H50O19Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Epimedin C and diphylloside A have antiinflammation effect, can reduce the swelling of the rats foot induced by egg. The accumulation of epimedinsA, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress.
    Targets: Immunology & Inflammation related
    In vitro:
    Acta Physiol Plant, 2013, 35(11):3271-5.
    Light stress suppresses the accumulation of epimedins A, B, C, and icariin in Epimedium, a traditional medicinal plant.[Reference: WebLink]
    Epimedium is well-known in China and East Asia due to high content of flavonoid derivatives, including icariin, Epimedin A, epimedin B, and Epimedin C, hereafter designated as bioactive components, which have been extensively utilized to cure many diseases. So far, the molecular mechanism of the bioactive components biosynthesis remains unclear.
    METHODS AND RESULTS:
    In the present study, the effect of light stress (24 h illumination) on the accumulation of bioactive components and the expression of flavonoid genes in Epimedium was investigated. Under light stress, the structural genes CHS1, CHI1, F3H, FLS, DFR1, DFR2, and ANS were remarkably up-regulated while CHS2 and F3′H were significantly down-regulated. For transcription factors, the expression of Epimedium MYB7 and TT8 were increased while Epimedium GL3, MYBF, and TTG1 expression were depressed. Additionally, the content of bioactive components was significantly decreased under light stress.
    CONCLUSIONS:
    Our results suggested that the decrease of bioactive compounds may be attributed to transcripts of late genes (DFRs and ANS) increased to a higher level than that of early genes (FLS and CHS1).
    In vivo:
    Chinese Journal of Modern Applied Pharmacy, 2012(3):198-201.
    Antiinflammatory Effect of Epimedin C and Diphylloside A of Epimedium Wushanense T.S.Ying.s.[Reference: WebLink]
    To study the antiinflammatory effect of Epimedin C and diphylloside A of Epimedium wushanense T.S.Ying.s on rats.
    METHODS AND RESULTS:
    Effect of Epimedin C and diphylloside A on swelling foot of rats induced by egg was assayed,degree of swelling was calculated,and compared with distilled water or indomethacin. Swelling of the rats foot induced by egg was reduced by Epimedin C and diphylloside A,and there was significant difference,compared with distilled water;and there was significant difference of Epimedin C in high dosage,compared with indomethacin,but there was no significant difference of Epimedin C in low dosage.
    CONCLUSIONS:
    Epimedin C and diphylloside A have antiinflammation effect.
    Epimedin C Description
    Source: The herbs of Epimedium brevicornum Maxim
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2154 mL 6.0768 mL 12.1536 mL 24.3072 mL 30.3841 mL
    5 mM 0.2431 mL 1.2154 mL 2.4307 mL 4.8614 mL 6.0768 mL
    10 mM 0.1215 mL 0.6077 mL 1.2154 mL 2.4307 mL 3.0384 mL
    50 mM 0.0243 mL 0.1215 mL 0.2431 mL 0.4861 mL 0.6077 mL
    100 mM 0.0122 mL 0.0608 mL 0.1215 mL 0.2431 mL 0.3038 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Biomed Chromatogr. 2014 Oct;28(10):1306-12.
    Metabolite profiles of epimedin C in rat plasma and bile by ultra-performance liquid chromatography coupled with quadrupole-TOF-MS.[Pubmed: 24853580]
    Epimedin C is one of the major bioactive constituents of Herba Epimedii. In this study, the metabolite profiles of Epimedin C in rat plasma and bile were qualitatively investigated, and the possible metabolic pathways of Epimedin C were subsequently proposed.
    METHODS AND RESULTS:
    After oral administration of Epimedin C at a single dose of 80 mg/kg, rat biological samples were collected and pretreated by protein precipitation. Then these pretreated samples were injected into an Acquity UPLC BEH C18 column and detected by ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. In all, 12 metabolites were identified in the biosamples. Of these, eight, two from plasma and six from bile, are, to our knowledge, reported here for the first time.
    CONCLUSIONS:
    The results indicated that Epimedin C was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. Thus, this study revealed the possible metabolite profiles of Epimedin C in rat plasma and bile.