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    Ethyl 2,4,6-trihydroxybenzoate
    Ethyl 2,4,6-trihydroxybenzoate
    CAS No. 90536-74-6 Price
    Catalog No.CFN96091Purity>=98%
    Molecular Weight198.2Type of CompoundPhenols
    FormulaC9H10O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Ethyl 2,4,6-trihydroxybenzoate suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes.
    2. Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
    Targets: Liver X Receptor
    Ethyl 2,4,6-trihydroxybenzoate Description
    Source: The herbs of Celtis biondii
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0454 mL 25.227 mL 50.4541 mL 100.9082 mL 126.1352 mL
    5 mM 1.0091 mL 5.0454 mL 10.0908 mL 20.1816 mL 25.227 mL
    10 mM 0.5045 mL 2.5227 mL 5.0454 mL 10.0908 mL 12.6135 mL
    50 mM 0.1009 mL 0.5045 mL 1.0091 mL 2.0182 mL 2.5227 mL
    100 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.0091 mL 1.2614 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Ethyl 2,4,6-trihydroxybenzoate References Information
    Citation [1]

    Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.

    Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed: 22579484 ]
    The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. In macrophages, hepatocytes, and intestinal cells, Ethyl 2,4,6-trihydroxybenzoate suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes. Notably, Ethyl 2,4,6-trihydroxybenzoate did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes. These results suggest that Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
    Citation [2]

    Asian Journal of Chemistry, 2005 , 17 (4) :2353-2358.

    Antimicrobial guided phytochemical evaluation of the pods of Caesalpinia pulcherrima[Reference: WebLink]
    The alcoholic extract of the pods of the plant C. pulcherrima afforded five antimicrobial compounds: four homoisoflavonids (4-O-methylsappanol, protosappanin A, brazilin and caesalpin J) and Ethyl 2,4,6-trihydroxybenzoate. The structures of the compounds were established by means of NMR spectroscopic analysis. Antimicrobial activity of the compounds was evaluated against pathogenic gram -ve and gram +ve bacteria and fungi.