|Description:||1. Ethyl 2,4,6-trihydroxybenzoate suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes.|
2. Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
|Targets:||Liver X Receptor|
|Source:||The herbs of Celtis biondii|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||5.0454 mL||25.227 mL||50.4541 mL||100.9082 mL||126.1352 mL|
|5 mM||1.0091 mL||5.0454 mL||10.0908 mL||20.1816 mL||25.227 mL|
|10 mM||0.5045 mL||2.5227 mL||5.0454 mL||10.0908 mL||12.6135 mL|
|50 mM||0.1009 mL||0.5045 mL||1.0091 mL||2.0182 mL||2.5227 mL|
|100 mM||0.0505 mL||0.2523 mL||0.5045 mL||1.0091 mL||1.2614 mL|
Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.
|Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed: 22579484 ]|
|The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. In macrophages, hepatocytes, and intestinal cells, Ethyl 2,4,6-trihydroxybenzoate suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes. Notably, Ethyl 2,4,6-trihydroxybenzoate did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes. These results suggest that Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.|
Asian Journal of Chemistry, 2005 , 17 (4) :2353-2358.
|Antimicrobial guided phytochemical evaluation of the pods of Caesalpinia pulcherrima[Reference: WebLink]|
|The alcoholic extract of the pods of the plant C. pulcherrima afforded five antimicrobial compounds: four homoisoflavonids (4-O-methylsappanol, protosappanin A, brazilin and caesalpin J) and Ethyl 2,4,6-trihydroxybenzoate. The structures of the compounds were established by means of NMR spectroscopic analysis. Antimicrobial activity of the compounds was evaluated against pathogenic gram -ve and gram +ve bacteria and fungi.|