|Source:||The fruiting bodys of Ganoderma lucidum|
|Biological Activity or Inhibitors:||1. Ganoderic acid F has anti-hepatitis B activity.
2. Ganoderic acid F has anti-inflammatory activity.
3. Ganoderic acid F has anti-tumor-promoting activity on highly invasive human breast cancer cells.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.7522 mL||8.7612 mL||17.5223 mL||35.0447 mL||43.8059 mL|
|5 mM||0.3504 mL||1.7522 mL||3.5045 mL||7.0089 mL||8.7612 mL|
|10 mM||0.1752 mL||0.8761 mL||1.7522 mL||3.5045 mL||4.3806 mL|
|50 mM||0.035 mL||0.1752 mL||0.3504 mL||0.7009 mL||0.8761 mL|
|100 mM||0.0175 mL||0.0876 mL||0.1752 mL||0.3504 mL||0.4381 mL|
Evid Based Complement Alternat Med. 2012;2012:780892.
|Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.[Pubmed: 22577465]|
|The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acid A and Ganoderic acid F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers. This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period. Each subject was randomly assigned to receive a single oral dose of 3,000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition). Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration. Plasma ganoderic acid A and Ganoderic acid F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique. In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (T(max) at approximately 30 min) and a short elimination half-life (<40 min). Food significantly decreased C(max) and delayed T(max), but did not affect the extent of ganoderic acid A absorption. However, concomitant food intake markedly impeded both rate and extent of Ganoderic acid F absorption.|