Ganoderic acid T-Q | CAS:112430-66-7 | Manufacturer ChemFaces

Ganoderic acid T-Q

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Ganoderic acid T-Q
Price:	$413 / 5 mg
CAS No.:	112430-66-7
Catalog No.:	CFN92237
Molecular Formula:	C₃₂H₄₆O₅
Molecular Weight:	510.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $475.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.

Targets:

H5N1 | H1N1

In vitro:

Scientific Reports, 2015, 5:13194.

Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.[Reference: WebLink]

Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority.
METHODS AND RESULTS:
Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of Ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1.
CONCLUSIONS:
These findings should prove valuable for the design and development of NA inhibitors.

Ganoderic acid T-Q Description

Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Journal of Natural Medicines,2018, 72(3):734-744.

Changes in content of triterpenoids and polysaccharides in Ganoderma lingzhi at different growth stages.[Reference: WebLink]

Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties.
METHODS AND RESULTS:
In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode. Total triterpenoid and total polysaccharide content were determined by colorimetric analysis. The results indicated that the fruit bodies at an early growth stage had a higher content of ganoderic acid A, C2, I and LM2, as well as of ganoderenic acid C and D, than those at a later growth stage. In contrast, ganoderic acid K, ganoderic acid TN and Ganoderic acid T-Q contents were higher in mature fruit bodies (maturation stage). The highest total triterpenoid and total polysaccharide contents were found in fruit bodies before maturity (stipe elongation stage or early stage of pileus formation).
CONCLUSIONS:
Our results provide information which will contribute to the establishment of an efficient cultivation system for G. lingzhi with a higher content of triterpenoids.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9581 mL	9.7905 mL	19.581 mL	39.1619 mL	48.9524 mL
5 mM	0.3916 mL	1.9581 mL	3.9162 mL	7.8324 mL	9.7905 mL
10 mM	0.1958 mL	0.979 mL	1.9581 mL	3.9162 mL	4.8952 mL
50 mM	0.0392 mL	0.1958 mL	0.3916 mL	0.7832 mL	0.979 mL
100 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.3916 mL	0.4895 mL

CFN90294	Ganoderic acid Y	86377-52-8	454.68	C₃₀H₄₆O₃
CFN97426	Ganoderic acid SZ	865543-37-9	452.7	C₃₀H₄₄O₃
CFN99066	Ganoderic acid S	104759-35-5	452.7	C₃₀H₄₄O₃
CFN90298	Ganoderic acid TN	112430-64-5	512.73	C₃₂H₄₈O₅
CFN92996	Ganoderic acid X	86377-53-9	512.72	C₃₂H₄₈O₅
CFN92997	Ganoderic acid Jb	112430-68-9	470.68	C₃₀H₄₆O₄
CFN92235	Ganoderic acid TR	862893-75-2	468.7	C₃₀H₄₄O₄
CFN92237	Ganoderic acid T-Q	112430-66-7	510.7	C₃₂H₄₆O₅
CFN99083	Coccinic acid	107783-45-9	454.7	C₃₀H₄₆O₃
CFN92727	Anwuweizonic acid	117020-59-4	454.7	C₃₀H₄₆O₃