ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Med.2015, 35(5):1237-45University of Limpopo2016, 1-237J Med Food.2016, 19(12):1155-1165J of the Korean Society of Food S...2016...Biochem Biophys Res Commun....2017...Front Pharmacol.2017, 8:673J Sci Food Agric.2017, 97(5):1656-1662Int J Mol Sci.2018, 19(9):E2601
J Sep Sci.2018, 41(9):1938-1946Primary and Industrial.2018, 52(11)Korean J. Crop Sci.2018, 63(2):131-139Biorxiv2019, 10.1101Front Aging Neurosci.2019, 11:230J Chromatogr B Analyt Technol Bio...2019...Plant Physiol Biochem.2019, 144:355-364J Pharm Biomed Anal.2019, 164:119-127
Exp Ther Med.2019, 18(6):4388-4396Food Chem.2019, 274:345-350Srinagarind Medical Journal2019, 34(1)Sci Rep.2019, 9(1):18080Metabolites.2019, 9(11):E271Appl. Sci.2020, 10,1304Psychopharmacology (Berl).2020, 10.1007
Our products had been exported to the following research institutions and universities, And still growing.
Uniwersytet Medyczny w ?odzi (Poland)Medical University of Gdansk (Poland)National Cancer Center Research... (Japan)University of Wuerzburg (Germany)
Heidelberg University (Germany)Universidad de La Salle (Mexico)The Institute of Cancer Research (United Kingdom)Utah State University (USA)
Complutense University of Madrid (Spain)Kitasato University (Japan)University of Mysore (India)
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
|| Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs. |
||H5N1 | H1N1|
|Scientific Reports, 2015, 5:13194. |
|Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.[Reference: WebLink]|
|Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority.
METHODS AND RESULTS:
Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of Ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1.
These findings should prove valuable for the design and development of NA inhibitors.
Ganoderic acid T-Q Description
||The fruit body of Ganoderma lucidum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Journal of Natural Medicines,2018, 72(3):734-744. |
|Changes in content of triterpenoids and polysaccharides in Ganoderma lingzhi at different growth stages.[Reference: WebLink]|
|Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties.
METHODS AND RESULTS:
In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode. Total triterpenoid and total polysaccharide content were determined by colorimetric analysis. The results indicated that the fruit bodies at an early growth stage had a higher content of ganoderic acid A, C2, I and LM2, as well as of ganoderenic acid C and D, than those at a later growth stage. In contrast, ganoderic acid K, ganoderic acid TN and Ganoderic acid T-Q contents were higher in mature fruit bodies (maturation stage). The highest total triterpenoid and total polysaccharide contents were found in fruit bodies before maturity (stipe elongation stage or early stage of pileus formation).
Our results provide information which will contribute to the establishment of an efficient cultivation system for G. lingzhi with a higher content of triterpenoids.