ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Sci Rep. Jan. 2018Plant Methods. 2017 Dec 6;Biochem Pharmacol. 2017 Apr 15;Braz J Med Biol Res. 2016 Jul 4;49(7).Biofactors.2017 Oct 24.
Food Chemistry.2015 Feb.7.Research on Crops.Jun 2017;Planta Med 2016 Apr 28.Journal of Analytical ChemistryAug. 2017;J. of Food Composition & Analysis2017
Korean j.of Pharm.Dec.2017;Molecules 2016, 21(6), 739;2016 Jun 14;21(6). Food Research InternationalApr. 2018;Phytomedicine1 Feb. 2018;
Our products had been exported to the following research institutions and universities, And still growing.
Korea Intitute of Science and Te... (Korea)Universidade do Porto (Portugal)Tohoku University (Japan)Nanjing University of Chinese Me... (China)
University of Padjajaran (Indonesia)University of Vigo (Spain)University of Ioannina (Greece)Michigan State University (USA)
University of Illinois (USA)Subang Jaya Medical Centre (Malaysia)Regional Crop Research Institute (Korea)
||Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.|
|International Journal of Food Microbiology Volume 174, 17 March 2014, Pages 47–55 |
|Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation[Reference: WebLink]|
|Infection by enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a worldwide problem, and there is no effective therapy. Biofilm formation is closely related to EHEC infection and is also a mechanism of antimicrobial resistance. |
METHODS AND RESULTS:
Antibiofilm screening of 560 purified phytochemicals against EHEC showed that ginkgolic acid C15:1 and Ginkgolic acid C17:1 at 5 μg/ml and Ginkgo biloba extract at 100 μg/ml significantly inhibited EHEC biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. Importantly, at their working concentrations, ginkgolic acids and G. biloba extract did not affect bacterial growth. Transcriptional analyses showed that ginkgolic acid C15:1 repressed curli genes and prophage genes in EHEC, and these findings were in-line with reduced fimbriae production and biofilm reductions. Interestingly, ginkgolic acids and G. biloba extract did not inhibit the biofilm formation of a commensal E. coli K-12 strain. In addition, ginkgolic acids and G. biloba extract inhibited the biofilm formation of three Staphylococcus aureus strains.
The findings of this study suggest that plant secondary metabolites represent an important resource for biofilm inhibitors.
Ginkgolic acid C17:1 Description
||The leaves of Ginkgo biloba L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.