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    Ginkgolic acid C17:1
    Information
    CAS No. 111047-30-4 Price $318 / 20mg
    Catalog No.CFN98508Purity>=98%
    Molecular Weight374.56Type of CompoundPhenols
    FormulaC24H38O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
    Targets: Antifection
    In vitro:
    International Journal of Food Microbiology Volume 174, 17 March 2014, Pages 47–55
    Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation[Reference: WebLink]
    Infection by enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a worldwide problem, and there is no effective therapy. Biofilm formation is closely related to EHEC infection and is also a mechanism of antimicrobial resistance.
    METHODS AND RESULTS:
    Antibiofilm screening of 560 purified phytochemicals against EHEC showed that ginkgolic acid C15:1 and Ginkgolic acid C17:1 at 5 μg/ml and Ginkgo biloba extract at 100 μg/ml significantly inhibited EHEC biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. Importantly, at their working concentrations, ginkgolic acids and G. biloba extract did not affect bacterial growth. Transcriptional analyses showed that ginkgolic acid C15:1 repressed curli genes and prophage genes in EHEC, and these findings were in-line with reduced fimbriae production and biofilm reductions. Interestingly, ginkgolic acids and G. biloba extract did not inhibit the biofilm formation of a commensal E. coli K-12 strain. In addition, ginkgolic acids and G. biloba extract inhibited the biofilm formation of three Staphylococcus aureus strains.
    CONCLUSIONS:
    The findings of this study suggest that plant secondary metabolites represent an important resource for biofilm inhibitors.
    Ginkgolic acid C17:1 Description
    Source: The leaves of Ginkgo biloba L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6698 mL 13.349 mL 26.698 mL 53.396 mL 66.745 mL
    5 mM 0.534 mL 2.6698 mL 5.3396 mL 10.6792 mL 13.349 mL
    10 mM 0.267 mL 1.3349 mL 2.6698 mL 5.3396 mL 6.6745 mL
    50 mM 0.0534 mL 0.267 mL 0.534 mL 1.0679 mL 1.3349 mL
    100 mM 0.0267 mL 0.1335 mL 0.267 mL 0.534 mL 0.6674 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.