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    Gnetol
    Information
    CAS No. 86361-55-9 Price $388 / 5mg
    Catalog No.CFN92425Purity>=98%
    Molecular Weight244.2Type of CompoundPhenols
    FormulaC14H12O4Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Gnetol Description
    Source: The herbs of Gnetum cleistostachynm
    Biological Activity or Inhibitors: 1. Gnetol has a strong inhibitory effect on murine tyrosinase activity.
    2. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells.
    3. Gnetol has the IC(50) value of 1.3 uM towards butyrylcholinesterase and shows a reversible and competitive inhibition in the kinetic study.
    4. Gnetol is active in the inhibition of arachidonic acid (AA)-induced platelet aggregation.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
    5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
    10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
    50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
    100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Gnetol References Information
    Citation [1]

    Biosci Biotechnol Biochem. 2003 Mar;67(3):663-5.

    Gnetol as a potent tyrosinase inhibitor from genus Gnetum.[Pubmed: 12723623]
    Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, Gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.
    Citation [2]

    Phytother Res. 2012 Oct;26(10):1564-8.

    Stilbenoids from Gnetum macrostachyum attenuate human platelet aggregation and adhesion.[Pubmed: 22511550 ]
    Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases. The phytochemical investigation of stilbenoids from Gnetum macrostachyum Hook. f. led to the isolation of trans-resveratrol (1), isorhapotigenin (2), Gnetol (3), bisisorhapontigenin B (4), gnetin C (5), parvifolol A (6), latifolol (7) and gnetuhainin C (8). The isolated stilbenoids were evaluated for in vitro antiplatelet activities via agonist-induced platelet aggregation and static platelet-collagen adhesion assays using washed human platelets. Compounds 1, 2 and 3 were active in the inhibition of arachidonic acid (AA)-induced platelet aggregation. Compound 2 and its dimer, compound 4, were the most active stilbenoids in thrombin-induced platelet aggregation. Moreover, compounds 4, 5 and 6, tended to be more potent than monomeric and trimeric stilbenoids in a human platelet-collagen adhesion assay under static conditions. This is the first report of the antiplatelet activity of stilbenoids isolated from G. macrostachyum.
    Citation [3]

    Fitoterapia. 2012 Jun;83(4):780-4.

    Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.[Pubmed: 22450264 ]
    Four stilbenes (1-4), one inseparable mixture of two alkyl diferulates (5a, 5b), one alkyl ferulate (6) and four flavonoids (7-10) were isolated from Ficus foveolata Wall. Except for quercetin (10), the other ten constituents were isolated from F. foveolata for the first time. In addition, one of the two components in mixture 5 is a new compound identified as (1E,22E)-1,22-docosanediol diferulate (5a). All nine isolated compounds, plus the mixture of 5a and 5b known as 5, exhibited a low or no activity against acetylcholinesterase. However, and interestingly, the stilbenes 1-4 showed a high inhibition towards butyrylcholinesterase. Gnetol (4) had the lowest IC(50) value of 1.3μM towards butyrylcholinesterase and showed a reversible and competitive inhibition in the kinetic study.