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  • Damulin B
    • Damulin B
    Damulin B
    Information
    CAS No. 1202868-75-4 Price $413 / 5mg
    Catalog No.CFN91837Purity>=98%
    Molecular Weight783.0Type of CompoundTriterpenoids
    FormulaC42H70O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $598.9 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Description: Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
    Targets: AMPK
    In vitro:
    Bioorganic & Medicinal Chemistry, 2011, 19(21):6254-6260.
    New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.[Pubmed: 21978948]
    AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism.
    METHODS AND RESULTS:
    In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and Damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulin A and Damulin B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells.
    CONCLUSIONS:
    Taken together our results indicate that activation of AMPK by Damulin A and Damulin B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
    Damulin B Description
    Source: The roots of Panax ginseng
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2771 mL 6.3857 mL 12.7714 mL 25.5428 mL 31.9285 mL
    5 mM 0.2554 mL 1.2771 mL 2.5543 mL 5.1086 mL 6.3857 mL
    10 mM 0.1277 mL 0.6386 mL 1.2771 mL 2.5543 mL 3.1928 mL
    50 mM 0.0255 mL 0.1277 mL 0.2554 mL 0.5109 mL 0.6386 mL
    100 mM 0.0128 mL 0.0639 mL 0.1277 mL 0.2554 mL 0.3193 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    CFN994773-Acetoxy-24-hydroxydammara-20,25-diene143519-04-4484.8 C32H52O3
    CFN92818Ginsenoside Rk2364779-14-6604.9C36H60O7
    CFN92644Ginsenoside Rk1494753-69-4767.0C42H70O12
    CFN99972Ginsenoside Rh3105558-26-7604.86C36H60O7
    CFN92643Ginsenoside Rg5186763-78-0767.0C42H70O12
    CFN91838Damulin A1202868-74-3783.0C42H70O13
    CFN91837Damulin B1202868-75-4783.0C42H70O13
    CFN92593Ginsenoside Rk3364779-15-7620.9C36H60O8
    CFN90565Ginsenoside Rg6147419-93-0766.5C42H70O12
    CFN92594Ginsenoside Rh4174721-08-5620.9C36H60O8
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