ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $598.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J. of Agricultural Science...2015...Phytother Res.2015, 29(7):1088-96J Agric Food Chem.2015, 63(44):9869-78Evid Based Complement Alternat Me...2016...Research on Crops.2017, 18(2)Evid Based Complement Alternat Me...2017...Sci Rep. 2017, 8207(7)Int J Mol Sci.2018, 19(9):E2601
Anticancer Res.2018, 38(4):2127-2135Food Res Int.2019, 123:125-134Microb Pathog.2019, 131:128-134Industrial Crops and Products...2019...Cardiovasc Toxicol.2019, 19(4):297-305Int J Mol Sci.2019, 20(21):E5488Chemistry of Plant Materials....2019...Molecules.2019, 24(23):E4303
Food Chem.2019, 274:345-350Chemistry of Vegetable Raw Materi...2019...Korean Journal of Pharmacognosy....2019...Cell Physiol Biochem....2019...J Food Sci Technol....2019...Sci Rep.2019, 9(1):18080Metabolites.2019, 9(11):E271
Our products had been exported to the following research institutions and universities, And still growing.
Complutense University of Madrid (Spain)University of Amsterdam (Netherlands)Medizinische Universit?t Wien (Austria)University of Wisconsin-Madison (USA)
Rio de Janeiro State University (Brazil)University of Bordeaux (France)National Cancer Center Research... (Japan)Worcester Polytechnic Institute (USA)
University of Medicine and Phar... (Romania)Anna University (India)Kazusa DNA Research Institute (Japan)
Related Screening Libraries
||Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.|
| Bioorganic & Medicinal Chemistry, 2011, 19(21):6254-6260. |
|New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.[Pubmed: 21978948]|
|AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism.|
METHODS AND RESULTS:
In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and Damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulin A and Damulin B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells.
Taken together our results indicate that activation of AMPK by Damulin A and Damulin B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
Damulin B Description
||The roots of Panax ginseng
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.