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    Hederasaponin B
    Information
    CAS No. 36284-77-2 Price $288 / 20mg
    Catalog No.CFN99986Purity>=98%
    Molecular Weight1205.4Type of CompoundTriterpenoids
    FormulaC59H96O25Physical DescriptionWhite powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis. It also has antitumor activity, and it inhibits the superoxide generation induced by arachidonic acid (AA).
    Targets: Antifection
    In vitro:
    Biomol Ther (Seoul). 2014 Jan;22(1):41-6.
    Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a.[Pubmed: 24596620]
    Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of Hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells.
    METHODS AND RESULTS:
    In the current study, the antiviral activity of Hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that Hederasaponin B and 30% ethanol extract of Hedera helix containing Hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.
    CONCLUSIONS:
    These results suggest that Hederasaponin B and Hedera helix extract containing Hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
    J Asian Nat Prod Res. 2009;11(2):122-7.
    Triterpenoid saponins from Anemone flaccida induce apoptosis activity in HeLa cells.[Pubmed: 19219723]
    Five triterpenoid saponins were isolated from Anemone flaccida Fr. Schmidt. Their structures were identified as glycoside St-I4a (1), glycoside St-J (2), anhuienoside E (3), Hederasaponin B (4), and flaccidoside II (5). Compounds 1-2 were isolated from Anemone family for the first time, and compounds 3-4 were isolated from this plant for the first time.
    METHODS AND RESULTS:
    The inhibitory effects of saponins on proliferation of HeLa cells were studied by MTT assay, the apoptosis-induction activity was observed by cell-cycle analysis and caspase-3 expression assay. The antitumor activities of the saponins were ranked in the following order: 5 > 3 > 4 > 1 > 2.
    CONCLUSIONS:
    The data presented here indicated that naturally occurring triterpenoid saponins can be regarded as excellent structures for the potential development of new anticancer agents.
    Fitoterapia. 2009 Mar;80(2):105-11.
    Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana.[Pubmed: 19084054]
    Four triterpenoid compounds hederacolchiside E (1), Hederasaponin B (2), raddeanoside 20 (3) and raddeanoside 21 (4) were isolated from ethanol extracts of rhizome of Anemone raddeana Regel.
    METHODS AND RESULTS:
    The effects of these triterpenoids on superoxide generation, tyrosyl phosphorylation of proteins and translocation of cytosolic compounds, such as p47(phox), p67(phox) and Rac to the cell membrane in human neutrophils was investigated. The superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) was slightly suppressed by Hederasaponin B, raddeanoside 20 and raddeanoside 21 in a concentration dependent manner. The superoxide generation induced by arachidonic acid (AA) was suppressed by Hederasaponin B and raddeanoside 21 significantly.
    CONCLUSIONS:
    fMLP- and AA-induced tyrosyl phosphorylation and translocation of the cytosolic proteins: p47(phox), p67(phox), and Rac to the cell membrane were suppressed in parallel with the suppression of stimulus-induced superoxide generation.
    Hederasaponin B Description
    Source: The herbs of Hedera nepalensis
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8296 mL 4.148 mL 8.296 mL 16.592 mL 20.74 mL
    5 mM 0.1659 mL 0.8296 mL 1.6592 mL 3.3184 mL 4.148 mL
    10 mM 0.083 mL 0.4148 mL 0.8296 mL 1.6592 mL 2.074 mL
    50 mM 0.0166 mL 0.083 mL 0.1659 mL 0.3318 mL 0.4148 mL
    100 mM 0.0083 mL 0.0415 mL 0.083 mL 0.1659 mL 0.2074 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Chromatogr Sci. 2015 Apr;53(4):478-83.
    Determination of saponins and flavonoids in ivy leaf extracts using HPLC-DAD.[Pubmed: 24981979]
    A new method for the determination of six compounds, chlorogenic acid, rutin, nicotiflorin, hederacoside C, Hederasaponin B and α-hederin, in ivy leaf extracts using high-performance liquid chromatography with diode array detector was developed.
    METHODS AND RESULTS:
    The chromatographic separation was performed on a YMC Hydrosphere C18 analytical column using a gradient elution of 0.1% phosphoric acid and acetonitrile. The method was validated in terms of specificity, linearity (r(2) > 0.9999), precision [relative standard deviation (RSD) < 0.36%] and accuracy (97.4-103.8%). The limit of detection and limit of quantification were <20.32 and 61.56 ng for all analytes, respectively. The tested compounds were found to be stable in the ivy leaf extract from 0 to 48 h, and the RSD value for each compound was <0.90%. The validated method was successfully applied to quantify all six compounds in a 30% ethanol ivy leaf extract and 13 ivy leaf extract products.
    CONCLUSIONS:
    The results showed that all the tested products satisfied the minimum requirement for the content of hederacoside C. However, there were some differences between the contents of other constituents.