ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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More articles cited ChemFaces products.
Biofactors.2017 Oct 24.LWT - Food Science and Technology2017 Jan.The Korea Society of Pharmacognosy.2014Acta Physiologiae Plantarum.2014 10.Nat Prod Sci.2016 Jun;22(2)
Korean j.of Pharm.Dec.2017;J Chromatogr B Analyt Tec. Bio. Life Sci. 2018 Feb 17;Molecules. 2018 Jan 24;Mol Med Rep.2014 May;9(5):1653-9.Universite de Bordeaux15 Dec 2017;
BMC Complement Altern Med.2014 Sep 23;14:352.Evid Based Complement Alternat Med. 2016 Jun 13.J Chromatogr B Analyt Tec. Bio. Life Sci. 2017 Oct 1;Polytechnic University of Catalonia2016
Our products had been exported to the following research institutions and universities, And still growing.
Tokyo Woman's Christian University (Japan)Weizmann Institute of Science (Israel)Imperial College London (United Kingdom)Vin?a Institute of Nuclear Scien... (Serbia)
Almansora University (Egypt)Charles Sturt University (Denmark)Technical University of Denmark (Denmark)Texas A&M University (USA)
Leibniz Institute of Plant Bioch... (Germany)Institute of Chinese Materia Med... (China)Mahatma Gandhi University (India)
|| Isofebrifugine shows antimalarial activity.|
|Phytother Res. 2003 Dec;17(10):1234-6. |
|Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice.[Pubmed: 14669265]|
|The combination effects of chloroquine with a mixture of febrifugine and Isofebrifugine were evaluated against a blood-induced infection with chloroquine-resistant P. berghei NK65 in ICR mice.
METHODS AND RESULTS:
Mice in the untreated control showed a progressively increasing parasitemia leading to mouse death. A two-day dosage of 20 mg base/kg of chloroquine alone showed little effect against P. berghei NK65 infection, and all mice died from day 13 to 14 with an increasing parasitemia. A four-day dosage of 1 mg/kg of the febrifugine and Isofebrifugine mixture alone showed a little antimalarial activity, but all mice died from day 19 to 27 with an increasing parasitemia. On the other hand, mice treated with chloroquine plus alkaloids survived during the experiment. All mice treated with chloroquine alone or the alkaloid mixture alone showed low parasitemia levels during a drug administration and following a few days, but then malaria parasites increased in the bloodstream of the treated mice until death. On the other hand, malaria parasites in the mice given chloroquine plus alkaloids decreased on day 6 and then were not detected by a microscopic examination during observation period.
|Journal of Natural Medicines, 2007 , 61 (2) :213-216. |
|Seasonal variation in the content of a febrifugine and isofebrifugine alkaloid mixture in aerial parts of Hydrangea macrophylla var. Otaksa, with special reference to its antimalarial activity[Reference: WebLink]|
|Febrifugine and Isofebrifugine alkaloid mixtures extracted from the leaves and buds of Hydrangea macrophylla var. Otaksa , collected during different months, in Japan, were quantified using high-performance liquid chromatography. |
METHODS AND RESULTS:
Leaves collected during the flowering season, namely from June to August, contained 0.16–0.3102mg/g of the alkaloid mixture, whereas those collected from September to December had less than 0.0302mg/g of the mixture. However, extracts of buds harvested from October to February contained a consistently larger amount (more than 0.4902mg/g) of the alkaloids. Hot-water extracts from the leaves and buds collected during different seasons were evaluated for antimalarial activity against Plasmodium yoelii 17XL in mice. The extract of leaves collected in August demonstrated high antimalarial activity, and all mice that received the extract survived the infection. In contrast, the extract of leaves collected in December showed little activity. The extract of buds collected in December cleared parasites, but with subsequent mortality to mouse.
The present results show that the amount of antimalarial agent—febrifugine and Isofebrifugine mixture—in H. macrophylla var. Otaksa is both part- and season-dependent, suggesting that the choice of plant parts and their harvesting season are important factors worth considering in the pharmacological use of medicinal plants.
||The roots of Dichroa febrifuga
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.