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Kuguacin N
Kuguacin N
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kuguacin N
Price:
CAS No.: 1141453-73-7
Catalog No.: CFN92074
Molecular Formula: C30H46O4
Molecular Weight: 470.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The fruits of Momordica charantia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kuguacin N has antioxidant activity.
Kuguacin N Description
Source: The fruits of Momordica charantia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1245 mL 10.6225 mL 21.245 mL 42.4899 mL 53.1124 mL
5 mM 0.4249 mL 2.1245 mL 4.249 mL 8.498 mL 10.6225 mL
10 mM 0.2124 mL 1.0622 mL 2.1245 mL 4.249 mL 5.3112 mL
50 mM 0.0425 mL 0.2124 mL 0.4249 mL 0.8498 mL 1.0622 mL
100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4249 mL 0.5311 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Scientia Agricultura Sinica, 2017.
Saponion Profiles and Antioxidant Activity,α-Glucosidase Inhibitory Activity of Momordica charantia of Different Varieties[Reference: WebLink]
The content and composition of saponion of 13 different M. charantia varieties as well as the antioxidant activity and inhibitory effect of α-glucosidase were studied.
METHODS AND RESULTS:
Perchloric acid-vanilin-glacial method was used to determine saponin content, while HPLC method was used to measure the contents of 7 saponin components. In addition, their antioxidant activity was evaluated by oxygen radical absorbance capacity (ORAC). The 4-nitrophenyl-2-β-D-glucopyranoside method was used to measure the a-glucosidase inhibitory activity and to analyze the relationship between the components and the corresponding activity. There is a significant difference in contents of saponin in 13 different varieties of M charantia.The content ranges of saponin were 0.52-1.20 g/100g DW, with an average value being 0.79 g/100g DW, and the coefficient of variability being 21.65%. The average contents of components were as follows: momorcharaside A 5.32 μg•g⁻¹ DW, momordicoside A 25.42 (μg•g⁻¹ DW, karaviloside XI 3.96 μg•g⁻¹ DW, momordicoside F2 66.95 μg•g⁻¹ DW, momordicoside K 183.70 μg•g⁻¹ DW, (23E)-3p,7p,25-trihydroxycucubita-5,23-dien-19-al 40.13 μg•g⁻¹ DW, and Kuguacin N 3.87 μg•g⁻¹ DW. ORAC values of the 13 M. charantia varieties varied from 2 747.76 to 15 584.07 μmol Trolox•g⁻¹, the average value being 8 879.48 mol Trolox•g⁻¹, the coefficient of variability being 34.91% and the IC50 value of alpha glucosidase varied from 1.55 to 4.96 mg•mL⁻¹.
CONCLUSIONS:
Significant differences in the components of saponin and the antioxidant activity and the inhibitory effect on α-glucosidase of different varieties of M. charantia were detected. Saponin is the main active basis of a-glucosidase activity in M. charantia, but not the main antioxidant substance. (23E)-3p,7p,25-trihydroxycucubita-5,23-dien-19-al is the major active compound.
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