ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules. 2013, 18(11):14105-21Mol Med Rep.2014, 9(5):1653-9Acta Pharm Sin B.2015, 5(4):323-9.Chemistr of plant2016, 2016021195BMC Complement Altern Med....2017...Cytotechnology.2017, 69(5):765-773Korean j.of Pharm.2017, 70-76Oncotarget.2017, 8(64):108006-108019
J Hematol Oncol.2018, 11(1):112ACS Nano.2018, 12(4):3385-3396PLoS One.2018, 13(4):e0195642Molecules.2018, 23(10):E2638Molecules.2018, 23(7):E1817Nat Prod Sci.2018, 24(2):109-114Asian Journal of Chemistry...2018...J Sci Food Agric.2018, 98(3):1153-1161
APMIS.2019, 127(10):688-695Molecules.2019, 25(1):E103Kor. J. Herbol.2019, 34(2):59-66J Mol Histol.2019, 50(4):343-354Ann Transl Med.2019, 7(23):731Process Biochemistry2019, 87:213-220Food and Chemical Toxicology...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Florida A&M University (USA)Universidad Industrial de Santa... (Colombia)Universidade Federal de Goias (... (Brazil)University of Otago (New Zealand)
University of East Anglia (United Kingdom)Korea Food Research Institute(K... (Korea)University of Virginia (USA)Nicolaus Copernicus Uniwersity (Poland)
University of Perugia (Italy)Mahatma Gandhi University (India)Universidade de Franca (Brazil)
Related Screening Libraries
|| Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.|
||PARP | Caspase|
Kuguaglycoside C Description
||The fruits of Momordica charantia
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Cancer Sci. 2012 Dec;103(12):2153-8. |
|Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells.[Pubmed: 22957888]|
|Kuguaglycoside C is a triterpene glycoside isolated from the leaves of Momordica charantia, and the biological effects of this compound remain almost unknown. |
METHODS AND RESULTS:
We investigated the anti-cancer effect of Kuguaglycoside C against human neuroblastoma IMR-32 cells. In the MTT assay, Kuguaglycoside C induced significant cytotoxicity against the IMR-32 cells (IC(50) : 12.6 μM) after 48 h treatment. Although examination by Hoechst 33342 staining revealed that Kuguaglycoside C induced nuclear shrinkage at a high concentration (100 μM), no apoptotic bodies were observed on flow cytometry. No activation of caspase-3 or caspase-9 was observed at the effective concentration (30 μM) of Kuguaglycoside C. On the other hand, the substance significantly decreased the expression of survivin and cleaved poly (ADP-ribose) polymerase (PARP). Kuguaglycoside C also significantly increased the expression and cleavage of apoptosis-inducing factor (AIF). Moreover, Kuguaglycoside C was found to induce caspase-independent DNA cleavage in the dual-fluorescence apoptosis detection assay.
These results suggest that Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.