Kuguaglycoside C | CAS:1041631-93-9 | Manufacturer ChemFaces

Kuguaglycoside C

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Kuguaglycoside C Description

Source:	The fruits of Momordica charantia
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Cancer Sci. 2012 Dec;103(12):2153-8.

Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells.[Pubmed: 22957888]

Kuguaglycoside C is a triterpene glycoside isolated from the leaves of Momordica charantia, and the biological effects of this compound remain almost unknown.
METHODS AND RESULTS:
We investigated the anti-cancer effect of Kuguaglycoside C against human neuroblastoma IMR-32 cells. In the MTT assay, Kuguaglycoside C induced significant cytotoxicity against the IMR-32 cells (IC(50) : 12.6 μM) after 48 h treatment. Although examination by Hoechst 33342 staining revealed that Kuguaglycoside C induced nuclear shrinkage at a high concentration (100 μM), no apoptotic bodies were observed on flow cytometry. No activation of caspase-3 or caspase-9 was observed at the effective concentration (30 μM) of Kuguaglycoside C. On the other hand, the substance significantly decreased the expression of survivin and cleaved poly (ADP-ribose) polymerase (PARP). Kuguaglycoside C also significantly increased the expression and cleavage of apoptosis-inducing factor (AIF). Moreover, Kuguaglycoside C was found to induce caspase-independent DNA cleavage in the dual-fluorescence apoptosis detection assay.
CONCLUSIONS:
These results suggest that Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.

Product Name	Kuguaglycoside C
Price:
CAS No.:	1041631-93-9
Catalog No.:	CFN92309
Molecular Formula:	C₃₆H₅₆O₈
Molecular Weight:	616.8 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruits of Momordica charantia
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pro-apoptotic Compound Library Triterpenoids Compound Library PARP Inhibitor Library Caspase Inhibitor Library

Description:	Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.
Targets:	PARP \| Caspase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6213 mL	8.1064 mL	16.2127 mL	32.4254 mL	40.5318 mL
5 mM	0.3243 mL	1.6213 mL	3.2425 mL	6.4851 mL	8.1064 mL
10 mM	0.1621 mL	0.8106 mL	1.6213 mL	3.2425 mL	4.0532 mL
50 mM	0.0324 mL	0.1621 mL	0.3243 mL	0.6485 mL	0.8106 mL
100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.3243 mL	0.4053 mL

CFN95170	Momordicoside X	1333321-50-8	634.9	C₃₆H₅₈O₉
CFN92305	Momordicoside K	81348-84-7	648.9	C₃₇H₆₀O₉
CFN95169	24-Hydroxymomordicine III	N/A	650.9	C₃₆H₅₈O₁₀
CFN92073	Kuguacin J	1141453-65-7	454.7	C₃₀H₄₆O₃
CFN92309	Kuguaglycoside C	1041631-93-9	616.8	C₃₆H₅₆O₈
CFN92076	Momordicine I	91590-76-0	472.7	C₃₀H₄₈O₄
CFN95167	Momordicine II	91590-75-9	634.9	C₃₆H₅₈O₉
CFN95164	Momordicine V	1012315-36-4	720.9	C₃₉H₆₀O₁₂
CFN92074	Kuguacin N	1141453-73-7	470.7	C₃₀H₄₆O₄
CFN95150	3,7,25-Trihydroxycucurbita-5,23-dien-19-al	85372-65-2	472.7	C₃₀H₄₈O₄