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    Kushenol X
    Information
    CAS No. 254886-77-6 Price $568 / 5mg
    Catalog No.CFN92390Purity>=98%
    Molecular Weight440.5Type of CompoundFlavonoids
    FormulaC25H28O7Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
    In vitro:
    Journal of Huazhong Normal University, 2014 , 48 (4) :520-4.
    Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescens[Reference: WebLink]
    To discover new bioactive Sodium-dependent glucose cotransporter 2(SGLT2)inhibitors from the traditional Chinese medicine"Ku Shen"(roots of Sophora flavescens),the bioassay-guided purification of an active ethyl acetate fraction was performed.
    METHODS AND RESULTS:
    Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2. Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively.
    Kushenol X Description
    Source: The roots of Sophora flavescens Ait.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2701 mL 11.3507 mL 22.7015 mL 45.403 mL 56.7537 mL
    5 mM 0.454 mL 2.2701 mL 4.5403 mL 9.0806 mL 11.3507 mL
    10 mM 0.227 mL 1.1351 mL 2.2701 mL 4.5403 mL 5.6754 mL
    50 mM 0.0454 mL 0.227 mL 0.454 mL 0.9081 mL 1.1351 mL
    100 mM 0.0227 mL 0.1135 mL 0.227 mL 0.454 mL 0.5675 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Planta Med. 2005 Nov;71(11):1065-8.
    Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor.[Pubmed: 16320211]
    Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae). The ability of 8-prenylkaempferol (1), Kushenol X (2), norkurarinone (3), leachianone A (4), kushenol C (5), maackiain (6) and a root-extract of S. flavescens to displace 17beta-estradiol (E2) from rat uterine estrogen receptor (ER) was determined.
    METHODS AND RESULTS:
    Relative binding affinities (RBA) of prenylated flavonoids were weak with RBA values between 0.004 and 0.072. A lavandulyl or prenyl group at the position 8 enhanced binding to rat uterine ER.
    Chromatographia, 2008 , 68 (5-6) :471-4.
    Simultaneous Determination of Nine Major Flavonoids in Sophora flavescens by RP-LC[Reference: WebLink]

    METHODS AND RESULTS:
    A liquid chromatographic method was applied to determine trifolirhizin, kushenol K, kushenol L, kushenol N, Kushenol X, kurarinone, norkurarinone, isokurarinone and kushenol A in the roots of Sophora flavescens, namely Kushen in China. The samples were separated on a YMC-C18 column (250 × 4.6 mm, 5 μm) with a gradient of methanol and 0.3% aqueous acetic acid (v/v) at a flow rate of 0.8 mL min−1 and detected at 295 nm. The complete separation was achieved within 45 min for the nine major flavonoids. All calibration curves expressed good linearity (r2 > 0.999) within the test range. The recovery of this method was 92.3–106.9%. The assay was successfully applied to the quantification of nine flavonoids in 26 samples of Kushen.
    CONCLUSIONS:
    The results indicated that this developed LC assay could be readily utilized as a quality control method for the Chinese herb medicine Kushen.