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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $568 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Evid Based Complement Alternat Me...2015...Food Science and Biotechnology...2015...China Pharmacy2015, 26(27)Korean J. of Food Sci. and Tech...2016...Food and Bioprocess Technology...2017...J Chromatogr B Analyt Technol Bio...2017...Phytochemistry.2017, 141:162-170Molecules.2017, 22(12)
Int. J. of Food Properties...2017...Integr Cancer Ther.2018, 17(3):832-843Korean J Environ Agric....2018...J Sep Sci.2018, 41(9):1938-1946Biofactors.2018, 44(2):168-179Pathogens.2018, 7(3):E62Academic J of Second Military Med...2019...Drug Des Devel Ther.2020, 14:61-71
Appl Biochem Biotechnol....2020...Advances in Traditional Medicine...2020...Nutrients.2020, 12(3):595.LWT2020, 126:109313LWT2020, 130:109535Evid Based Complement Alternat Me...2020...J Biotechnol.2020, 318:10-19.
Our products had been exported to the following research institutions and universities, And still growing.
Cornell University (USA)Universidade Federal de Santa C... (Brazil)Shanghai Institute of Organic C... (China)University of Amsterdam (Netherlands)
Medical University of South Car... (USA)Universiti Malaysia Pahang (Malaysia)University of Limpopo (South Africa)Ain Shams University (Egypt)
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Related Screening Libraries
|| Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). |
|Journal of Huazhong Normal University, 2014 , 48 (4) :520-4. |
|Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescens[Reference: WebLink]|
|To discover new bioactive Sodium-dependent glucose cotransporter 2(SGLT2)inhibitors from the traditional Chinese medicine"Ku Shen"(roots of Sophora flavescens),the bioassay-guided purification of an active ethyl acetate fraction was performed.
METHODS AND RESULTS:
Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2.
Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively.
Kushenol X Description
||The roots of Sophora flavescens Ait.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Planta Med. 2005 Nov;71(11):1065-8. |
|Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor.[Pubmed: 16320211]|
|Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae). The ability of 8-prenylkaempferol (1), Kushenol X (2), norkurarinone (3), leachianone A (4), kushenol C (5), maackiain (6) and a root-extract of S. flavescens to displace 17beta-estradiol (E2) from rat uterine estrogen receptor (ER) was determined.
METHODS AND RESULTS:
Relative binding affinities (RBA) of prenylated flavonoids were weak with RBA values between 0.004 and 0.072. A lavandulyl or prenyl group at the position 8 enhanced binding to rat uterine ER.
|Chromatographia, 2008 , 68 (5-6) :471-4. |
|Simultaneous Determination of Nine Major Flavonoids in Sophora flavescens by RP-LC[Reference: WebLink]|
METHODS AND RESULTS:
A liquid chromatographic method was applied to determine trifolirhizin, kushenol K, kushenol L, kushenol N, Kushenol X, kurarinone, norkurarinone, isokurarinone and kushenol A in the roots of Sophora flavescens, namely Kushen in China. The samples were separated on a YMC-C18 column (250 × 4.6 mm, 5 μm) with a gradient of methanol and 0.3% aqueous acetic acid (v/v) at a flow rate of 0.8 mL min−1 and detected at 295 nm. The complete separation was achieved within 45 min for the nine major flavonoids. All calibration curves expressed good linearity (r2 > 0.999) within the test range. The recovery of this method was 92.3–106.9%. The assay was successfully applied to the quantification of nine flavonoids in 26 samples of Kushen.
The results indicated that this developed LC assay could be readily utilized as a quality control method for the Chinese herb medicine Kushen.