Kusunokinin | CAS:58311-20-9 | Manufacturer ChemFaces

Kusunokinin

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Kusunokinin Description

Source:	The roots of Daphne odora
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kusunokinin References Information

Citation [1]

Planta Med. 2010 Sep;76(13):1454-6.

Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera.[Pubmed: 20301059 ]

Bioguided fractionation of extract from the leaves of Aristolochia cymbifera led to the isolation of the furofuran lignans fargesin, epieudesmin, and sesamin; the dibenzylbutyrolactone lignans hinokinin and Kusunokinin; and an ENT-labdane diterpene named copalic acid. Our data demonstrated that copalic acid and Kusunokinin were the most active compounds against trypomastigotes of Trypanosoma cruzi. Additionally, copalic acid demonstrated the highest parasite selectivity as a result of low toxicity to mammalian cells, despite a considerable hemolytic activity at higher concentrations. Among the isolated compounds, Kusunokinin could be considered the most promising candidate, as it displayed significant activity against intracellular amastigotes (IC(50) = 17 µM) and trypomastigotes (IC(50) = 51 µM) without hemolytic activity. Fargesin, hinokinin, epieudesmin, and sesamin were also effective against trypomastigotes, but these compounds were highly toxic to mammalian cells and no parasite selectivity could be identified. The need for novel drugs for American trypanosomiasis is evident, and these secondary metabolites from A. cymbifera represent a useful tool for drug design.

Product Name	Kusunokinin
Price:
CAS No.:	58311-20-9
Catalog No.:	CFN92254
Molecular Formula:	C₂₁H₂₂O₆
Molecular Weight:	370.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Cryst.
Source:	The roots of Daphne odora
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-trypanosoma Compound Library Lignans Compound Library Antifection Inhibitor Library

Description:	Kusunokinin displays significant activity against intracellular amastigotes (IC(50) = 17 µM) and trypomastigotes (IC(50) = 51 µM) without hemolytic activity.
Targets:	Antifection

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6998 mL	13.4989 mL	26.9978 mL	53.9957 mL	67.4946 mL
5 mM	0.54 mL	2.6998 mL	5.3996 mL	10.7991 mL	13.4989 mL
10 mM	0.27 mL	1.3499 mL	2.6998 mL	5.3996 mL	6.7495 mL
50 mM	0.054 mL	0.27 mL	0.54 mL	1.0799 mL	1.3499 mL
100 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.6749 mL

CFN92255	(-)-Hinokinin	26543-89-5	354.4	C₂₀H₁₈O₆
CFN98635	Yatein	40456-50-6	400.4	C₂₂H₂₄O₇
CFN92816	Epinortrachelogenin	125072-69-7	374.4	C₂₀H₂₂O₇
CFN99534	Arctigenin	7770-78-7	372.41	C₂₁H₂₄O₆
CFN99991	Arctiin	20362-31-6	534.55	C₂₇H₃₄O₁₁
CFN90714	Arctigenin 4'-O-beta-gentiobioside	41682-24-0	696.69	C₃₃H₄₄O₁₆
CFN89301	Matairesinoside	23202-85-9	520.53	C₂₆H₃₂O₁₁
CFN90715	Matairesinol 4'-O-beta-gentiobioside	106647-14-7	682.25	C₃₂H₄₂O₁₆
CFN92253	(-)-Haplomyrfolin	85404-48-4	356.4	C₂₀H₂₀O₆
CFN92254	Kusunokinin	58311-20-9	370.4	C₂₁H₂₂O₆