Ginsenoside Rg6 | CAS:147419-93-0 | Price: $318/5mg

Ginsenoside Rg6

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Size /Price /Stock	10 mM * 1 mL in DMSO / $461.1 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Ginsenoside Rg6 Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Molecules. 2013 Jul 9;18(7):8109-19.

Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells.[Pubmed: 23839115]

In this communication our aim was to study the JK cell growth inhibitory and apoptosis-inducing effects of Ginsenoside Rg6 (GRg6) from steamed notoginseng on human lymphocytoma.
METHODS AND RESULTS:
The CCK-8 method was used to observe the anti-proliferative effect of GRg6 on human lymphocytoma JK cells. Flow cytometry was performed to analyze the influence of GRg6 on cell cycle. The Annexin-V FITC/PI double-staining method was used to detect the ratio of apoptotic cells. JC-1 staining was undertaken to observe the influence of GRg6 on intracellular mitochondrial membrane potential. Finally, western blots were conducted to detect the expression level of apoptosis-related Bax and the Bcl-2 proteins. The results suggested that GRg6 can inhibit the proliferation of human lymphocytoma JK cells. GRg6 blocks an S arrest in the cell cycle. With the increase in GRg6 concentration, the potential in the cell decreased in a dose dependent manner, and Bax protein expression gradually increased, whereas Bcl-2 protein expression gradually decreased.
CONCLUSIONS:
In conclusion, GRg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis. The mechanism of action may be related to mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression caused by GRg6.

CAS No.	147419-93-0	Price	$318 / 5mg
Catalog No.	CFN90565	Purity	>=98%
Molecular Weight	766.5	Type of Compound	Triterpenoids
Formula	C₄₂H₇₀O₁₂	Physical Description	Powder
Download	Manual COA MSDS	Similar structural	Comparison (Web)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-wrinkle Compound Library Triterpenoids Compound Library Bcl-2/Bax Inhibitor Library

Description:	Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression.
Targets:	Bcl-2/Bax

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3046 mL	6.5232 mL	13.0463 mL	26.0926 mL	32.6158 mL
5 mM	0.2609 mL	1.3046 mL	2.6093 mL	5.2185 mL	6.5232 mL
10 mM	0.1305 mL	0.6523 mL	1.3046 mL	2.6093 mL	3.2616 mL
50 mM	0.0261 mL	0.1305 mL	0.2609 mL	0.5219 mL	0.6523 mL
100 mM	0.013 mL	0.0652 mL	0.1305 mL	0.2609 mL	0.3262 mL

CFN92818	Ginsenoside Rk2	364779-14-6	604.9	C₃₆H₆₀O₇
CFN92644	Ginsenoside Rk1	494753-69-4	767.0	C₄₂H₇₀O₁₂
CFN99972	Ginsenoside Rh3	105558-26-7	604.86	C₃₆H₆₀O₇
CFN92643	Ginsenoside Rg5	186763-78-0	767.0	C₄₂H₇₀O₁₂
CFN91838	Damulin A	1202868-74-3	783.0	C₄₂H₇₀O₁₃
CFN91837	Damulin B	1202868-75-4	783.0	C₄₂H₇₀O₁₃
CFN92593	Ginsenoside Rk3	364779-15-7	620.9	C₃₆H₆₀O₈
CFN90565	Ginsenoside Rg6	147419-93-0	766.5	C₄₂H₇₀O₁₂
CFN92594	Ginsenoside Rh4	174721-08-5	620.9	C₃₆H₆₀O₈
CFN90572	Ginsenoside Rg4	126223-28-7	767.0	C₄₂H₇₀O₁₂