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  • Ginsenoside Rg6
    • Ginsenoside Rg6
    Ginsenoside Rg6
    Information
    CAS No. 147419-93-0 Price $318 / 5mg
    Catalog No.CFN90565Purity>=98%
    Molecular Weight766.5Type of CompoundTriterpenoids
    FormulaC42H70O12Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    • Biological Activity
    Description: Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression.
    Targets: Bcl-2/Bax
    Ginsenoside Rg6 Description
    Source: The roots of Panax ginseng C. A. Mey.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3046 mL 6.5232 mL 13.0463 mL 26.0926 mL 32.6158 mL
    5 mM 0.2609 mL 1.3046 mL 2.6093 mL 5.2185 mL 6.5232 mL
    10 mM 0.1305 mL 0.6523 mL 1.3046 mL 2.6093 mL 3.2616 mL
    50 mM 0.0261 mL 0.1305 mL 0.2609 mL 0.5219 mL 0.6523 mL
    100 mM 0.013 mL 0.0652 mL 0.1305 mL 0.2609 mL 0.3262 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Molecules. 2013 Jul 9;18(7):8109-19.
    Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells.[Pubmed: 23839115]
    In this communication our aim was to study the JK cell growth inhibitory and apoptosis-inducing effects of Ginsenoside Rg6 (GRg6) from steamed notoginseng on human lymphocytoma.
    METHODS AND RESULTS:
    The CCK-8 method was used to observe the anti-proliferative effect of GRg6 on human lymphocytoma JK cells. Flow cytometry was performed to analyze the influence of GRg6 on cell cycle. The Annexin-V FITC/PI double-staining method was used to detect the ratio of apoptotic cells. JC-1 staining was undertaken to observe the influence of GRg6 on intracellular mitochondrial membrane potential. Finally, western blots were conducted to detect the expression level of apoptosis-related Bax and the Bcl-2 proteins. The results suggested that GRg6 can inhibit the proliferation of human lymphocytoma JK cells. GRg6 blocks an S arrest in the cell cycle. With the increase in GRg6 concentration, the potential in the cell decreased in a dose dependent manner, and Bax protein expression gradually increased, whereas Bcl-2 protein expression gradually decreased.
    CONCLUSIONS:
    In conclusion, GRg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis. The mechanism of action may be related to mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression caused by GRg6.
    CFN92593Ginsenoside Rk3364779-15-7620.9C36H60O8
    CFN90565Ginsenoside Rg6147419-93-0766.5C42H70O12
    CFN92594Ginsenoside Rh4174721-08-5620.9C36H60O8
    CFN90572Ginsenoside Rg4126223-28-7767.0C42H70O12
    CFN994773-Acetoxy-24-hydroxydammara-20,25-diene143519-04-4484.8 C32H52O3
    CFN92818Ginsenoside Rk2364779-14-6604.9C36H60O7
    CFN92644Ginsenoside Rk1494753-69-4767.0C42H70O12
    CFN99972Ginsenoside Rh3105558-26-7604.86C36H60O7
    CFN92643Ginsenoside Rg5186763-78-0767.0C42H70O12
    CFN91838Damulin A1202868-74-3783.0C42H70O13
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