ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Antiviral Res.2013, 98(3):386-93Acta Agriculturae Scandinavica...2015...Evid Based Complement Alternat Me...2016...PLoS One.2017, 12(8):e0181191Plant Methods.2017, 13:108The Japan Society for Analy. Chem...2017...Int J Biol Macromol.2018, 112:1093-1103Neuropharmacology.2018, 131:68-82
European Journal of Integrative M...2018...Sci Adv.2018, 4(10)Phytomedicine.2018, 40:37-47Korean Journal of Pharmacognosy...2018...The Japan Society for Analytical ...2018...Sci Rep.2018, 8:15059Biochemical Systematics and Ecolo...2018...Virulence.2018, 9(1):588-603
APMIS.2019, 127(10):688-695J Adv Res.2019, 17:85-94Int J Mol Sci.2019, 20(23):E6071Korean Journal of Pharmacognosy...2019...Sci Rep.2019, 9(1):4646J Cell Physiol.2020, 10.1002Plant Foods Hum Nutr.2020, 10.1007
Our products had been exported to the following research institutions and universities, And still growing.
Massachusetts General Hospital (USA)University of Bonn (Germany)University of Virginia (USA)University of Toulouse (France)
S.N.D.T. Women's University (India)Sanford Burnham Prebys Medical ... (USA)University of British Columbia (Canada)Universidad de La Salle (Mexico)
Auburn University (USA)Universiti Sains Malaysia (Malaysia)Univerzita Karlova v Praze (Czech Republic)
Related Screening Libraries
||Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm.
||AChR | POP|
|Nat Prod Res. 2017 Jun;31(12):1459-1463. |
|Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil.[Pubmed: 27834099 ]|
METHODS AND RESULTS:
Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid Leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors.
Extracts obtained by maceration were active against POP (53-58%), but showed weak activity against AChE. The isolated Leojaponin and leonurine were evaluated as POP inhibitors.
|Phytother Res. 2010 Aug;24(8):1256-9. |
|Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity.[Pubmed: 20658574]|
|To examine the cytoprotective effects of Leonurus japonicus Houtt, its protection against the glutamate-induced toxicity in primary cortical cultured neurons was tested.|
METHODS AND RESULTS:
In order to clarify the cytoprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. By such fractionation, three known diterpenes--prehispanolone (1), Leojaponin (2) and iso-preleoheterin (3)--were isolated from the methanol extracts from the air-dried L. japonicus. Among these three compounds, Leojaponin (2) exhibited significant cytoprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microm to 10 microm.
Therefore, the cytoprotective effect of L. japonicus might be due to the inhibition of glutamate-induced toxicity by the diterpenes it contains.
||The aerial parts of Leonurus sibiricus L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.