ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Inflammation2015, 38(1):445-55J. Soc. Cosmet. Sci. Korea2016, 163-171University of Limpopo2016, 1777Front Pharmacol.2016, 7:460Free Radic Biol Med.2017, 112:191-199Food Chem.2017, 228:301-314Pharmacognosy Magazine...2018...Mol Pharm.2018, 15(8):3285-3296
Journal of functional foods...2018...Industrial Crops and Products...2018...Korean J Environ Agric....2018...Phytomedicine.2018, 41:62-66Biomol Ther (Seoul).2019, 10.4062Chemistry of Plant Materials....2019...J Ethnopharmacol.2019, 228:132-141Phytother Res.2019, 33(4):1104-1113
Srinagarind Medical Journal2019, 34(1)Academic J of Second Military Med...2019...New Journal of Chemistry...2019...Pharmacol Rep.2019, 71(2):289-298Sci Rep.2019, 9:12132Neurochem Int.2020, 133:104629J Pharmaceut Biomed2020, 178:112894
Our products had been exported to the following research institutions and universities, And still growing.
Mendel University in Brno (Czech Republic)Monash University Malaysia (Malaysia)University of Hertfordshire (United Kingdom)University of Minnesota (USA)
The Australian National University (Australia)University of Maryland (USA)FORTH-IMBB (Greece)Universidade Federal de Goias (... (Brazil)
Ain Shams University (Egypt)Shanghai Institute of Biochemis... (China)Universiti Sains Malaysia (Malaysia)
Related Screening Libraries
|| Limonol-derivatives could as promising scaffolds for the design of novel Hsp90α inhibitors. |
||Raf | ATPase | Akt | HSP (e.g. HSP90)|
|Fitoterapia. 2000 Jun;71(3):317-20. |
|Antifungal activity of some tetranortriterpenoids.[Pubmed: 10844171]|
METHODS AND RESULTS:
Natural tetranortriterpenoids such as cedrelone from Toona ciliata, azadiradione from Azadirachta indica, limonin, Limonol and nomilinic acid from Citrus medica, along with some cedrelone derivatives were tested for their antifungal activity against Puccinia arachidis, a groundnut rust pathogen. Results show that cedrelone was the most effective in reducing rust pustule emergence.
Replacement of functional groups or modification of the A or the B ring in cedrelone reduced the effectiveness indicating the importance of specific structural features for activity.
|Chemistry. 2016 Sep 5;22(37):13236-50. |
|Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.[Pubmed: 27492719 ]|
|The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies. |
METHODS AND RESULTS:
In an attempt to identify new small molecules modulating the activity of Hsp90, we screened a small library of tetranortriterpenes. A high-affinity interaction with Hsp90 inducible form was uncovered for eight of these compounds, five of which are described here for the first time. By monitoring the ATPase activity and the citrate synthase thermal induced aggregation, compound 1 (cedrelosin A), 3 (7α-limonylacetate), and 5 (cedrelosin B), containing a Limonol moiety, were found to be the most effective in compromising the Hsp90α chaperone activity. Consistent with these findings, the three compounds caused a depletion of c-Raf and pAkt Hsp90 client proteins in HeLa and MCF/7 cell lines. Induced fit docking protocol and molecular dynamics were used to rationalize the structural basis of the biological activity of the Limonol derivatives.
Taken together, these results point to Limonol-derivatives as promising scaffolds for the design of novel Hsp90α inhibitors.
||The barks of Melia azedarach L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytochemistry.1982; 21(9):2349-2354. |
|7α-Oxygenated limonoids from the rutaceae.[Reference: WebLink]|
METHODS AND RESULTS:
Limonol, deoxyLimonol, and 7α-obacunol were isolated from Citrus paradisi seeds. Limonyl acetate and 7α-obacunyl acetate were isolated from fru.