ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Arch Pharm Res.2015, 38(6):1080-9Analytical sci. & Tech2016, 186-193Oncol Rep.2016, 35(3):1356-64Food Analytical Methods...2017...J Chromatogr B Analyt Technol Bio...2017...African J. Agricultural Research ...2017...PLoS One.2017, 12(8):e0181191J. of The Korean Society of Food ...2017...
J Ethnopharmacol.2017, 206:73-77Molecules.2017, 22(3)Cell Physiol Biochem....2017...RSC Advances2017, 86Journal of functional foods...2018...South African J of Plant&Soil...2018...Journal of Life Science2018, 917-922Nutrients.2019, 11(11):E2694
J of Essential Oil Research...2019...Evid Based Complement Alternat Me...2019...Molecules.2019, 24(7):E1290Trop J Nat Prod Res.2019, 3(1):6-9TCI CO.2019, US20190151281A1Saudi Pharm J2020, 10.1016Cell Metab.2020, S1550-4131(20)30002-4
Our products had been exported to the following research institutions and universities, And still growing.
Korea Institute of Oriental Med... (Korea)University of Hertfordshire (United Kingdom)Melbourne University (Australia)Washington State University (USA)
Kamphaengphet Rajabhat University (Thailand)Uniwersytet Gdański (Poland)Monash University (Australia)University of Eastern Finland (Finland)
Tokyo Woman's Christian University (Japan)Charles University in Prague (Czech Republic)Universidade de Franca (Brazil)
Related Screening Libraries
||Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity. |
|Cancer Lett. 1999 Apr 26;138(1-2):87-92. |
|Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay.[Pubmed: 10378778 ]|
METHODS AND RESULTS:
In a search for anti-tumor-promoting agents, we carried out a primary screening of twenty-nine 8-substituted and four 6-substituted derivatives of 7-methoxycoumarins isolated from plants of the Murraya and/or Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. This investigation indicated that the prenyl (3-methyl-2-butenyl) or 2-hydroxy-3-methylbutyl (or butenyl) unit as an isoprenoid moiety at C-8 on the 7-methoxycoumarin nucleus plays an important role in the anti-tumor-promoting activity.
Some of the 8-substituted 7-methoxycoumarins isolated from Murraya species, murrangatin (7), Minumicrolin (10) and chloticol (18), were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that 7, 10 and 18 might be valuable anti-tumor-promoting agents.
|J Asian Nat Prod Res. 2008 May-Jun;10(5-6):515-9. |
|Two new coumarins from Murraya paniculata.[Pubmed: 18470803 ]|
METHODS AND RESULTS:
Two new coumarins, murrmeranzin (1) and murralonginal (2), together with four known compounds Minumicrolin (3), murrangatin (4), meranzin hydrate (5) and hainanmurpanin (6) have been isolated from the aerial parts of Murraya paniculata. The structures of these compounds were determined through spectral analysis.
Minumicrolin (3) showed mild butyrylcholinesterase inhibition activity.
|Biosci Biotechnol Biochem. 2000 Feb;64(2):420-3. |
|Coumarin-related compounds as plant growth inhibitors from two rutaceous plants in Thailand.[Pubmed: 10737204 ]|
METHODS AND RESULTS:
Chemical investigation of naturally occurring plant growth inhibitors from Rutaceous plants in Thailand led us to identify five 7-methoxycoumarins and one 5,7-dimethoxycoumarin from Murraya paniculata, and six furanocoumarins from Citrus aurantifolia.
Of these compounds, murranganon senecioate (1) is a new natural compound found in M. paniculata.
Minumicrolin (6) was found to be highly active against the 2nd leaf sheath elongation of rice seedlings.
||The herbs of Murraya exotica L
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Arch Pharm Res. 2011 Apr;34(4):527-31. |
|C-7 oxygenated coumarins from the fruits of Micromelum minutum.[Pubmed: 21544717 ]|
METHODS AND RESULTS:
A new 7-oxygenated coumarin, 7-demethylmurralonginol isovalerate (1), and a new natural product, murralonginol (2), together with seven known 7-oxygenated coumarins, murralonginol isovalerate (3), murralongin (4), micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and Minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data.
Among these isolates, compounds 2 and 4 - 9 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.