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Jionoside A1
Jionoside A1
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Jionoside A1
Price: $238 / 5mg
CAS No.: 120444-60-2
Catalog No.: CFN90809
Molecular Formula: C36H48O20
Molecular Weight: 800.8 g/mol
Purity: >=98%
Type of Compound: Polyphenols
Physical Desc.: Powder
Source: The roots of Rehmannia glutinosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $380.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Jionoside A1 displays dose dependent immune-enhancement activity and possesses moderate neuroprotective activities on H2O2-treated SH-SY5Y cells.
Targets: Immunology & Inflammation related
In vitro:
J. Pharm. Biomed. Anal., 2015, 117(6):363-71.
Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS(n) combined with bioassays.[Pubmed: 26433168 ]
Fufang Ejiao Syrup (FES) is a widely used immune-boosting Traditional Chinese Medicine (TCM) in Eastern Asian countries. This study attempts to investigate the bioactive compounds in FES.
METHODS AND RESULTS:
First, FES extract was separated into fractions to facilitate the investigation and 72 compounds were identified using LC-MS(n). Subsequently, Immune-enhancement effects of FES and its components were investigated on bone marrow cells and neuroprotective effects against H2O2 induced oxidative damage were evaluated in SH-SY5Y neuroblastoma cells and bEnd.3. Our results indicated that fraction 3, 5, 6 and 8 showed significant improvements on immune function, while several fractions had cytoprotective effects against H2O2-induced oxidative injury. Jionoside A1 isolated from Radix Rehmanniae Praeparata displayed dose dependent immune-enhancement activity. 20(R)-ginsenoside Rg3 could protect bEnd.3 against oxidative damage. Furthermore, echinacoside, Jionoside A1, vitexin-2-O-rhamnoside, acteoside and isoacteoside possessed moderate protective activities on H2O2-treated SH-SY5Y cells.
CONCLUSIONS:
In conclusion, our study provided both chemical and biological evidences to support clinical application of FES.
Jionoside A1 Description
Source: The roots of Rehmannia glutinosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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IF=13.297(2019)

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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2488 mL 6.2438 mL 12.4875 mL 24.975 mL 31.2188 mL
5 mM 0.2498 mL 1.2488 mL 2.4975 mL 4.995 mL 6.2438 mL
10 mM 0.1249 mL 0.6244 mL 1.2488 mL 2.4975 mL 3.1219 mL
50 mM 0.025 mL 0.1249 mL 0.2498 mL 0.4995 mL 0.6244 mL
100 mM 0.0125 mL 0.0624 mL 0.1249 mL 0.2498 mL 0.3122 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN98522Calceolarioside A84744-28-5478.44C23H26O11
CFN89370Desrhamnosylmartynoside136055-64-6506.49C25H30O11
CFN95714Cistantubuloside B1130009-44-8770.7C35H46O19
CFN99715Forsythoside B81525-13-5756.70C34H44O19
CFN99714Poliumoside94079-81-9770.73C35H46O19
CFN90882Brandioside133393-81-4812.8C37H48O20
CFN98105Echinacoside82854-37-3786.72C35H46O20
CFN950352'-Rhamnoechinacoside1422390-59-7932.9C41H56O24
CFN93410Purpureaside C108648-07-3786.7C35H46O20
CFN90809Jionoside A1120444-60-2800.8C36H48O20
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