Mirificin | CAS:103654-50-8 | Price: $198/20mg

Mirificin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $92.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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In vitro:

Molecules. 2015 Oct 15;20(10):18704-16.

Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer.[Pubmed: 26501241]

Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal flora (HIF) and intestinal absorption deserves study.
METHODS AND RESULTS:
In this work TMF extract was incubated with human intestinal bacteria under anaerobic conditions and the changes in the twelve main constituents of TMF were then investigated. Their intestinal permeabilities, i.e., the transport capability across the intestinal brush border were investigated with a human colon carcinoma cell line (Caco-2) cell monolayer model to predict the absorption mechanism. Meanwhile, rapid HPLC-DAD methods were established for the assay. According to the biotransformation curves of the twelve constituents and the permeability coefficients, the intestinal absorption capacity of the typical compounds was elevated from the levels of 10(-7) cm/s to 10(-5) cm/s from those of the original compounds in TMF. Among them the main isoflavone glycosides puerarin (4), Mirificin (6) and daidzin (7) were transformed into the same aglycone, daidzein (10).
CONCLUSIONS:
Therefore it was predicted that the aglycone compounds might be the real active ingredients in TMF. The models used can represent a novel path for the TCM studies.

Mirificin Description

Source:	The roots of Pueraria lobata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

《Journal of Instrumental Analysis》 2013-04

Simultaneous Determination of Puerarin,3-Methoxy Puerarin,Mirificin and Daidzin in the Bioactive Fraction of Naodesheng Prescription by RP-HPLC/UV Method[Reference: WebLink]

METHODS AND RESULTS:
A reversed-phase high performance liquid chromatography coupled with UV detection(RP-HPLC/UV) was developed and validated for the simultaneous determination of four isoflavonoids,including puerarin(PU),3-methoxy puerarin(MP),Mirificin(MI) and daidzin(DA),in the bioactive fraction of Naodesheng prescription,i.e.a widely used herbal medicine(HM) in China mainly for treatment of cerebral arteriosclerosis,ischemic stroke,sequelae of cerebral hemorrhage and etc.The separation of four compounds was accomplished on a Hyspersil ODS-2 column(250 mm×4.6 mm,5 μm i.d.) by using methanol-water(25 ∶ 75) as mobile phase with isocratic elution at a flow rate of 0.9 mL/min.The UV detection wavelength was set at 250 nm,and the column temperature was 25 ℃.The high resolution and reproducible peaks were achieved for four compounds in 20 min.All the calibration curves showed good linearities(r≥0.999 7) over the test concentration range.The relative standard deviations(RSDs) of the method were less than 2.2% for precision,stability and reproducibility assays,and the spiked recoveries were in the range of 96%-102%.
CONCLUSIONS:
The total contents of the four isoflavonoids were determined to be in the range of 37.3%-37.8%in the bioactive fraction of Naodesheng prescription.

CAS No.	103654-50-8	Price	$198 / 20mg
Catalog No.	CFN90643	Purity	>=98%
Molecular Weight	548.49	Type of Compound	Flavonoids
Formula	C₂₆H₂₈O₁₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8232 mL	9.1159 mL	18.2319 mL	36.4637 mL	45.5797 mL
5 mM	0.3646 mL	1.8232 mL	3.6464 mL	7.2927 mL	9.1159 mL
10 mM	0.1823 mL	0.9116 mL	1.8232 mL	3.6464 mL	4.558 mL
50 mM	0.0365 mL	0.1823 mL	0.3646 mL	0.7293 mL	0.9116 mL
100 mM	0.0182 mL	0.0912 mL	0.1823 mL	0.3646 mL	0.4558 mL

CFN70353	Genistein 7-O-glucuronide	38482-81-4	446.4	C₂₁H₁₈O₁₁
CFN93006	4''-methyloxy-Genistin	950910-16-4	446.40	C₂₂H₂₂O₁₀
CFN89471	Ambocin	108044-05-9	564.49	C₂₆H₂₈O₁₄
CFN95185	New compound 4	N/A	578.5	C₂₇H₃₀O₁₄
CFN95166	Lanceolarin	15914-68-8	578.5	C₂₇H₃₀O₁₄
CFN97005	Sissotrin	5928-26-7	446.4	C₂₂H₂₂O₁₀
CFN90953	Genistein 7,4'-di-O-beta-D-glucopyranoside	36190-98-4	594.52	C₂₇H₃₀O₁₅
CFN90631	6''-O-Malonylgenistin	51011-05-3	518.42	C₂₄H₂₂O₁₃
CFN99105	Glycitin	40246-10-4	446.41	C₂₂H₂₂O₁₀
CFN93455	6''-O-Acetylglycitin	134859-96-4	488.44	C₂₄H₂₄O₁₁