|Source:||The root barks of Morus alba L.|
|Biological Activity or Inhibitors:|| 1. Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be used as a skin whitening agent.
|Solvent:||Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.7652 mL||8.8261 mL||17.6523 mL||35.3045 mL||44.1306 mL|
|5 mM||0.353 mL||1.7652 mL||3.5305 mL||7.0609 mL||8.8261 mL|
|10 mM||0.1765 mL||0.8826 mL||1.7652 mL||3.5305 mL||4.4131 mL|
|50 mM||0.0353 mL||0.1765 mL||0.353 mL||0.7061 mL||0.8826 mL|
|100 mM||0.0177 mL||0.0883 mL||0.1765 mL||0.353 mL||0.4413 mL|
Biol Pharm Bull. 2002 Aug;25(8):1045-8.
|Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.[Pubmed: 12186407]|
|The current study was carried out to investigate the in vitro effects of an 85% methanol extract of dried Morus alba leaves on melanin biosynthesis, which is closely related to hyperpigmentation. These extracts inhibited the tyrosinase activity that converts dopa to dopachrome in the biosynthetic process of melanin. Mulberroside F (moracin M-6, 3'-di-O-beta-D-glucopyranoside), which was obtained after the bioactivity-guided fractionation of the extracts, showed inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. This compound also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation. But its activity was low and was weaker than of kojic acid. These results suggest that Mulberroside F isolated from mulberry leaves might be used as a skin whitening agent.|